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MICA

MICA,全稱為人類MHC-I類分子鏈相關(guān)基因A蛋白,是一種主要在腫瘤細胞表面表達的免疫原性蛋白。該蛋白常見別名包括MHC class I chain-related antigen A、CD155等。MICA蛋白與NKG2D受體結(jié)合,激活NK細胞和CD8+ T細胞,從而殺傷腫瘤細胞。在腫瘤免疫逃逸中,MICA蛋白的表達下調(diào)或脫落是常見機制。針對MICA蛋白的藥物研發(fā)已成為腫瘤免疫治療的重要方向。目前,已有多種靶向MICA蛋白的單克隆抗體進入臨床試驗階段,如CLN-619和Genentech的1D5V11抗體。這些藥物通過阻斷MICA蛋白與NKG2D受體的結(jié)合,或抑制MICA蛋白的脫落,從而增強NK細胞和T細胞對腫瘤細胞的殺傷作用。此外,還有研究探索MICA蛋白在其他疾病中的作用,如自身免疫性疾病和病毒感染等。MICA蛋白的研究為腫瘤免疫治療提供了新的思路和策略,有望為癌癥患者帶來新的治療選擇。

熱銷產(chǎn)品

MICA Recombinant Monoclonal Antibody (CSB-RA574653A0HU)

驗證數(shù)據(jù)

CSB-RA574653A0HU

IHC image of CSB-RA574653A0HU diluted at 1:80 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.49% DAB.

CSB-RA574653A0HU

IHC image of CSB-RA574653A0HU diluted at 1:80 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.49% DAB.

MICA Antibody (CSB-PA013806ESR2HU)

驗證數(shù)據(jù)

CSB-PA013806ESR2HU

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA013806ESR2HU at dilution of 1:100

CSB-PA013806ESR2HU

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA013806ESR2HU at dilution of 1:100

Human major histocompatibility complex class I chain-related gene A (MICA) ELISA Kit (CSB-E13782h)

驗證數(shù)據(jù)

CSB-E13782h 標(biāo)準(zhǔn)曲線

貨號:CSB-E13782h

規(guī)格:96T/48T

靈敏度:0.39 ng/mL

檢測范圍:1.56 ng/mL-100 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

MICA Antibodies

MICA for Homo sapiens (Human)

MICA ELISA Kit

MICA ELISA Kit for Homo sapiens (Human)



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