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MASP2

MASP2,即甘露聚糖結合凝集素相關絲氨酸蛋白酶2,它是由人體編碼的蛋白質,屬于補體系統的一部分。MASP2主要來源于肝臟,是凝集素途徑中的關鍵效應酶。其作用機制是在凝集素途徑激活后,MASP2被甘露糖結合凝集素(MBL)或其他模式識別分子激活,進而裂解C4和C2,形成C3轉化酶,激活C3和C5,最終導致形成膜攻擊復合物(MAC),發揮溶細胞效應。在信號通路方面,MASP2的激活是補體系統凝集素途徑的中心環節,通過其絲氨酸蛋白酶活性,MASP2參與調控免疫反應和炎癥過程。在生物學意義上,MASP2對宿主的免疫防御至關重要,其功能異常與多種炎癥性疾病和自身免疫性疾病的發生發展相關。MASP2的活性調節為治療相關疾病提供了新的策略。

熱銷產品

Recombinant Human Mannan-binding lectin serine protease 2 (MASP2) (CSB-EP013510HU)

驗證數據

CSB-EP013510HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

MASP2 Antibody (CSB-PA013510LA01HU)

驗證數據

CSB-PA013510LA01HU

IHC image of CSB-PA013510LA01HU diluted at 1:100 and staining in paraffin-embedded human melanoma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Human mannan-binding lectin serine peptidase 2 (MASP2)ELISA kit (CSB-E17966h)

驗證數據

CSB-E17966h 標準曲線

貨號:CSB-E17966h

規格:96T/48T

靈敏度:5.86 pg/mL

檢測范圍:23.44 pg/mL-1500 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

MASP2 Antibodies

MASP2 for Homo sapiens (Human)

MASP2 Proteins

MASP2 Proteins for Homo sapiens (Human)

MASP2 Proteins for Mus musculus (Mouse)

MASP2 Proteins for Rattus norvegicus (Rat)

MASP2 ELISA Kit

MASP2 ELISA Kit for Homo sapiens (Human)

MASP2 ELISA Kit for Mus musculus (Mouse)



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