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MAPKAP1

Target of rapamycin complex 2 subunit MAPKAP1 is a protein in humans that is encoded by MAPKAP1 gene. Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'.

MAPKAP1 Antibodies

MAPKAP1 for Homo sapiens (Human)

MAPKAP1 Proteins

MAPKAP1 Proteins for Bos taurus (Bovine)

MAPKAP1 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

MAPKAP1 Proteins for Rattus norvegicus (Rat)

MAPKAP1 Proteins for Pongo abelii (Sumatran orangutan)

MAPKAP1 Proteins for Ovis aries (Sheep)

MAPKAP1 Proteins for Xenopus laevis (African clawed frog)

MAPKAP1 Proteins for Mus musculus (Mouse)

MAPKAP1 Proteins for Homo sapiens (Human)

MAPKAP1 Proteins for Gallus gallus (Chicken)



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