LTA

LTA基因編碼TNF-β蛋白（腫瘤壞死因子β），也稱為淋巴毒素α（Lymphotoxin Alpha，LT-α），屬于TNSF超家族一員。根據TNF來源的不同，人們將單核/巨噬細胞所產生的TNF稱腫瘤壞死因子α；把T細胞產生的TNF稱為腫瘤壞死因子（TNF-β）。TNF-β有膜結合和可溶性兩種形式，分泌到細胞外的可溶性形式稱為LT-α。LT-α主要由活化的CD4+CD8+T細胞、NK細胞、B淋巴母細胞樣細胞、骨髓瘤細胞等產生。LT-α在細菌的代謝和致病過程中發揮重要的作用。研究證實在感染結核分支桿菌后，遺傳性LT-a缺陷的小鼠比LT-a正常小鼠屯集更多的細菌負荷量。TNF-β除了介導許多炎癥、免疫刺激和抗病毒應答。在發育階段，TNF-β還參與二級淋巴器官的形成，并在凋亡中發揮作用。在TNF-β敲除小鼠中，所有派伊爾氏淋巴集結和淋巴結都無法發育，這表明了TNF-β在免疫系統發育中的重要性。

Recombinant Human LTA 活性蛋白實驗驗證數據

High Purity Validated
by SDS-PAGE

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Excellent Bioactivity Validated by Functional ELISA

Measured by its binding ability in a functional ELISA. Immobilized LTA at 5 μg/ml can bind human TNFRSF1B (CSB-MP023978HU2), the EC₅₀ is 1.632-2.699 ng/ml.

Excellent Bioactivity Validated by Functional ELISA

Measured by its binding ability in a functional ELISA. Immobilized LTA at 5 μg/ml can bind human TNFR1(CSB-MP023977HU1), the EC₅₀ of human LTA protein is 4.409-6.797 ng/ml.

LTA Antibody

LTA Protein

LTA ELISA Kit

LTA Antibodies

LTA for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA013218KA01HU	LTA Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA004313	LTA Antibody	Human,Mouse,Rat,Monkey	WB, ELISA
CSB-PA863040	LTA Antibody	Human	ELISA,IHC
CSB-RA013218A0HU	LTA Recombinant Monoclonal Antibody	Human	ELISA

LTA Proteins

LTA Proteins for Oryctolagus cuniculus (Rabbit)

產品貨號	產品名稱	來源
CSB-YP013218RB CSB-EP013218RB CSB-BP013218RB CSB-MP013218RB CSB-EP013218RB-B	Recombinant Rabbit Lymphotoxin-alpha (LTA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

LTA Proteins for Sus scrofa (Pig)

產品貨號	產品名稱	來源
CSB-YP013218PI CSB-EP013218PI CSB-BP013218PI CSB-MP013218PI CSB-EP013218PI-B	Recombinant Pig Lymphotoxin-alpha (LTA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

LTA Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP013218HU CSB-EP013218HU CSB-BP013218HU CSB-EP013218HU-B	Recombinant Human Lymphotoxin-alpha (LTA)	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-AP002171HU	Recombinant Human Lymphotoxin-alpha protein (LTA)	E.Coli
CSB-AP004941HU	Recombinant Human Lymphotoxin-alpha (LTA) (Active)	E.coli
CSB-MP013218HU	Recombinant Human Lymphotoxin-alpha (LTA) (Active)	Mammalian cell
CSB-MP013218HU-B	Recombinant Human Lymphotoxin-alpha (LTA), partial,Biotinylated	Mammalian cell

LTA Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP013218MO CSB-BP013218MO CSB-MP013218MO CSB-EP013218MO-B	Recombinant Mouse Lymphotoxin-alpha (Lta)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP013218MO	Recombinant Mouse Lymphotoxin-alpha (Lta)	E.coli
CSB-EP013218MOa0	Recombinant Mouse Lymphotoxin-alpha (Lta)	E.coli

LTA Proteins for Pan troglodytes (Chimpanzee)

產品貨號	產品名稱	來源
CSB-YP013218EQV CSB-EP013218EQV CSB-BP013218EQV CSB-MP013218EQV CSB-EP013218EQV-B	Recombinant Pan troglodytes Lymphotoxin-alpha (LTA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

LTA Proteins for Macaca mulatta (Rhesus macaque)

產品貨號	產品名稱	來源
CSB-YP713142MOW CSB-EP713142MOW CSB-BP713142MOW CSB-MP713142MOW CSB-EP713142MOW-B	Recombinant Macaca mulatta Lymphotoxin-alpha (LTA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

LTA Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

產品貨號	產品名稱	來源
CSB-YP730213DO CSB-EP730213DO CSB-BP730213DO CSB-MP730213DO CSB-EP730213DO-B	Recombinant Dog Lymphotoxin-alpha (LTA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

LTA Proteins for Marmota monax (Woodchuck)

產品貨號	產品名稱	來源
CSB-YP862417MQG CSB-EP862417MQG CSB-BP862417MQG CSB-MP862417MQG CSB-EP862417MQG-B	Recombinant Marmota monax Lymphotoxin-alpha (LTA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

LTA Proteins for Macropus eugenii (Tammar wallaby)

產品貨號	產品名稱	來源
CSB-YP894074MPE CSB-EP894074MPE CSB-BP894074MPE CSB-MP894074MPE CSB-EP894074MPE-B	Recombinant Macropus eugenii Lymphotoxin-alpha (LTA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli