LRP8
LRP8，全稱(chēng)為低密度脂蛋白受體相關(guān)蛋白8，是一種廣泛存在于人體細(xì)胞表面的蛋白質(zhì)，尤其在腦部組織中高表達(dá)。該蛋白具有多種別名，包括ApoER2、HSZ75190、LRP-8和MCI1。LRP8參與多種生理過(guò)程，如脂質(zhì)代謝和神經(jīng)元遷移。在疾病方面，LRP8與多種疾病的發(fā)生發(fā)展密切相關(guān)，包括阿爾茨海默病、心血管疾病和某些神經(jīng)系統(tǒng)疾病。研究表明，LRP8的表達(dá)水平與阿爾茨海默病的嚴(yán)重程度呈負(fù)相關(guān)，提示其可能成為阿爾茨海默病的潛在治療靶點(diǎn)。此外，LRP8還在心血管疾病的發(fā)生發(fā)展中發(fā)揮重要作用，其異常表達(dá)可能導(dǎo)致血脂異常和動(dòng)脈粥樣硬化。在藥物研發(fā)方面，針對(duì)LRP8的藥物正在研發(fā)中，例如，有研究者在開(kāi)發(fā)基于LRP8的單克隆抗體，用于治療阿爾茨海默病和心血管疾病。
熱銷(xiāo)產(chǎn)品
LRP8 Recombinant Monoclonal Antibody (CSB-RA825731A0HU)
驗(yàn)證數(shù)據(jù)
Flow cytometric analysis of LDL receptor related protein 8 expression in HepG2 cells using LDL receptor related protein 8 antibody. Green, isotype control; red, LDL receptor related protein 8.
Immunocytochemical staining of HepG2 cells with LDL receptor related protein 8 antibody. Nuclei were stained blue with DAPI; LDL receptor related protein 8 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
Western blotting analysis using LDL receptor related protein 8 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with LDL receptor related protein 8 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
LRP8 Antibody (CSB-PA623900LA01HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: SH-SY5Y whole cell lysate, A549 whole cell lysate, U87 whole cell lysate
All lanes: LRP8 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 106, 78, 100, 88 kDa
Observed band size: 106 kDa
Immunofluorescent analysis of HepG2 cells using CSB-PA623900LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
LRP8 Antibodies
LRP8 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA030286 | LRP8 Antibody | Human | WB, ELISA |
| CSB-PA623900LA01HU | LRP8 Antibody | Human | ELISA, WB, IF |
| CSB-PA623900LC01HU | LRP8 Antibody, FITC conjugated | Human | |
| CSB-PA623900LD01HU | LRP8 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA825731A0HU | LRP8 Recombinant Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB, FC, ICC |
LRP8 Proteins
LRP8 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP623900HU CSB-EP623900HU CSB-BP623900HU CSB-MP623900HU CSB-EP623900HU-B |
Recombinant Human Low-density lipoprotein receptor-related protein 8 (LRP8), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
