LIMK1
LIMK1，全稱為LIM結構域激酶1，是一種與細胞骨架結構和突觸可塑性密切相關的蛋白。它屬于LIM激酶家族，該家族的蛋白通過調控肌動蛋白動力學在多種細胞過程中發揮作用。LIMK1蛋白通過磷酸化和失活肌動蛋白結合因子cofilin來調節肌動蛋白聚合，從而影響細胞形態和運動。這種蛋白在發育過程中廣泛表達，并在許多與細胞骨架結構相關的細胞過程中發揮作用，如神經元軸突生長和神經突觸可塑性。LIMK1蛋白的異常表達或功能失調與多種疾病相關，包括神經退行性疾病如阿爾茨海默病和帕金森病，以及脆性X綜合征等。目前，研究人員正在開發針對LIMK1蛋白的抑制劑，以治療這些疾病。例如，有研究開發出一種名為SM311的LIMK1抑制劑，它能夠選擇性抑制LIMK1蛋白，并在動物實驗中顯示出改善記憶力的效果。這些研究為LIMK1蛋白相關疾病的治療提供了新的思路和方法。
熱銷產品
Recombinant Human LIM domain kinase 1 (LIMK1) (CSB-MP012952HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
LIMK1 Antibody (CSB-PA012952LA01HU)
驗證數據
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA012952LA01HU at dilution of 1:100
LIMK1 Antibodies
LIMK1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA012952GA01HU | LIMK1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA697195 | Phospho-LIMK1 (Thr508) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA828577 | LIMK1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA000566 | Phospho-LIMK1 (T508) Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA003150 | LIMK1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA009830 | LIMK1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA782037 | LIMK1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA042400 | LIMK1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA012952LA01HU | LIMK1 Antibody | Human | ELISA, IHC |
| CSB-PA012952LB01HU | LIMK1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA012952LC01HU | LIMK1 Antibody, FITC conjugated | Human | |
| CSB-PA012952LD01HU | LIMK1 Antibody, Biotin conjugated | Human | ELISA |
LIMK1 Proteins
LIMK1 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP012952MO CSB-EP012952MO CSB-BP012952MO CSB-MP012952MO CSB-EP012952MO-B |
Recombinant Mouse LIM domain kinase 1 (Limk1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LIMK1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP012952HU CSB-EP012952HU CSB-BP012952HU CSB-EP012952HU-B |
Recombinant Human LIM domain kinase 1 (LIMK1) | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP012952HU | Recombinant Human LIM domain kinase 1 (LIMK1) | Mammalian cell |
LIMK1 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP012952RA CSB-EP012952RA CSB-BP012952RA CSB-MP012952RA CSB-EP012952RA-B |
Recombinant Rat LIM domain kinase 1 (Limk1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LIMK1 Proteins for Xenopus laevis (African clawed frog)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP012952XBE CSB-EP012952XBE CSB-BP012952XBE CSB-MP012952XBE CSB-EP012952XBE-B |
Recombinant Xenopus laevis LIM domain kinase 1 (limk1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LIMK1 Proteins for Drosophila melanogaster (Fruit fly)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP012952DLU CSB-EP012952DLU CSB-BP012952DLU CSB-MP012952DLU CSB-EP012952DLU-B |
Recombinant Drosophila melanogaster LIM domain kinase 1 (LIMK1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LIMK1 Proteins for Gallus gallus (Chicken)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP012952CH CSB-EP012952CH CSB-BP012952CH CSB-MP012952CH CSB-EP012952CH-B |
Recombinant Chicken LIM domain kinase 1 (LIMK1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
