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LANCL2

LANCL2,即羊毛硫氨酸合成酶C樣蛋白2,別名TASP。它是一種脫落酸受體,表達(dá)于人的免疫細(xì)胞、上皮細(xì)胞和肌肉細(xì)胞中,參與應(yīng)激反應(yīng)、組織生長(zhǎng)、炎癥調(diào)節(jié)和糖代謝等信號(hào)傳遞。LANCL2的作用機(jī)制包括與ABA結(jié)合,激活信號(hào)傳導(dǎo),增強(qiáng)調(diào)節(jié)性T細(xì)胞(Treg)反應(yīng),下調(diào)腸道中的效應(yīng)反應(yīng),并參與線粒體代謝和IL-2/CD25信號(hào)傳導(dǎo)的免疫調(diào)節(jié)。LANCL2的藥理學(xué)激活在腸道炎癥、系統(tǒng)性紅斑狼瘡、類風(fēng)濕性關(guān)節(jié)炎、多發(fā)性硬化癥和牛皮癬的小鼠模型中顯示出治療功效。此外,LANCL2還參與了膠質(zhì)母細(xì)胞瘤的侵襲性偽足形成和腫瘤進(jìn)展,通過激活STAT3/Cortactin信號(hào)通路。LANCL2的異常表達(dá)與多種疾病的發(fā)病機(jī)制相關(guān),包括自身免疫性疾病和腫瘤,如膠質(zhì)母細(xì)胞瘤。因此,LANCL2不僅在細(xì)胞抗氧化過程中發(fā)揮作用,還可能成為未來(lái)治療這些疾病的潛在靶點(diǎn)。

熱銷產(chǎn)品

LANCL2 Antibody (CSB-PA865129LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA865129LA01HU

Western Blot
Positive WB detected in: A549 whole cell lysate, U87 whole cell lysate
All lanes: LANCL2 antibody at 3.5µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 51 kDa
Observed band size: 51 kDa

CSB-PA865129LA01HU

IHC image of CSB-PA865129LA01HU diluted at 1:300 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA865129LA01HU

Immunofluorescence staining of HepG2 cells with CSB-PA865129LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

LANCL2 Antibodies

LANCL2 for Homo sapiens (Human)

LANCL2 Proteins

LANCL2 Proteins for Homo sapiens (Human)



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