KLRC1
KLRC1，全稱為殺傷細(xì)胞凝集素樣受體C1，也被稱為NKG2A、CD159a、NK細(xì)胞受體A。KLRC1主要表達(dá)在NK細(xì)胞表面，屬于NKG2家族成員，與另一個(gè)家族成員KLRD1/CD94形成異二聚體，識(shí)別MHC I類HLA-E分子。KLRC1通過與HLA-E結(jié)合，負(fù)調(diào)控NK細(xì)胞、CD8+ T細(xì)胞等的免疫活性，參與腫瘤及病毒感染細(xì)胞的殺傷。研究發(fā)現(xiàn)，KLRC1在哮喘患者中表達(dá)上調(diào)，提示檢測KLRC1受體水平可以用于哮喘的臨床診斷、直接反映哮喘控制情況，以及KLRC1抗體運(yùn)用于哮喘疾病防治的應(yīng)用。目前，針對KLRC1的藥物研發(fā)主要集中在NKG2A抑制劑，例如莫那利珠單抗（Monalizumab）和阿斯利康開發(fā)的Interlink-1試驗(yàn)。莫那利珠單抗是一種NKG2A抗體單抗，可阻斷NKG2A與HLA-E的相互作用，在多種癌癥適應(yīng)癥中展現(xiàn)出良好的治療效果。然而，NKG2A抑制劑的上市還需要更大規(guī)模的臨床試驗(yàn)進(jìn)行驗(yàn)證。
熱銷產(chǎn)品
KLRC1 Antibody (CSB-PA012466ESR1HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA012466ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA012466ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA012466ESR1HU at dilution of 1:100
KLRC1 Antibodies
KLRC1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA012466GA01HU | KLRC1 Antibody | Human | ELISA,WB,IHC |
| CSB-PA012466ESR1HU | KLRC1 Antibody | Human | ELISA, IHC |
| CSB-PA919911 | KLRC1 Antibody | Human | ELISA,WB |
| CSB-PA005326 | KLRC1 Antibody | Human | WB, ELISA |
| CSB-PA009651 | KLRC1 Antibody | Human | WB, ELISA |
| CSB-PA073427 | KLRC1 Antibody | Human | ELISA,IHC |
| CSB-PA911316 | KLRC1 Antibody | Human | ELISA,IHC |
KLRC1 Proteins
KLRC1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP012466HU1 CSB-EP012466HU1 CSB-BP012466HU1 CSB-MP012466HU1 CSB-EP012466HU1-B |
Recombinant Human NKG2-A/NKG2-B type II integral membrane protein (KLRC1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF012466HU | Recombinant Human NKG2-A/NKG2-B type II integral membrane protein (KLRC1) | in vitro E.coli expression system |
KLRC1 Proteins for Pan troglodytes (Chimpanzee)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP856823EQV CSB-EP856823EQV CSB-BP856823EQV CSB-MP856823EQV CSB-EP856823EQV-B |
Recombinant Pan troglodytes NKG2-A/NKG2-B type II integral membrane protein (KLRC1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
