KLK5
KLK5是激肽釋放酶家族中的一種絲氨酸蛋白酶，在人體中發(fā)揮著多重功能。它主要參與皮膚的生理脫屑過程，維持皮膚細胞的正常更新。然而，KLK5活性的上調(diào)可能引發(fā)連續(xù)的皮膚脫屑，激活蛋白酶激活受體-2（PAR2），導(dǎo)致促炎細胞因子的釋放，從而破壞表皮屏障功能，與炎癥性皮膚病的發(fā)展密切相關(guān)。此外，KLK5還可能通過剪切Cathelicidin產(chǎn)生活性形式LL-37，參與到玫瑰痤瘡等疾病的免疫調(diào)節(jié)過程中。盡管其具體分子結(jié)構(gòu)和直接參與的信號通路尚需深入研究，但KLK5在皮膚健康、細胞增殖、凋亡及免疫調(diào)節(jié)中的重要作用已不容忽視。
熱銷產(chǎn)品
KLK5 Antibody (CSB-PA897100LA01HU)
驗證數(shù)據(jù)
Western blot
All lanes: KLK5 antibody at 2μg/ml + MCF-7 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 32 kDa
Observed band size: 32 kDa
Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA897100LA01HU at dilution of 1:100
KLK5 Antibodies
KLK5 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA012456GA01HU | KLK5 Antibody | Human | ELISA |
| CSB-PA897100LA01HU | KLK5 Antibody | Human | ELISA, WB, IHC |
| CSB-PA897100LC01HU | KLK5 Antibody, FITC conjugated | Human | |
| CSB-PA175566 | KLK5 Antibody | Human,Mouse | ELISA,WB,IHC |
KLK5 Proteins
KLK5 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP897100HU CSB-EP897100HU CSB-BP897100HU CSB-MP897100HU CSB-EP897100HU-B |
Recombinant Human Kallikrein-5 (KLK5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KLK5 ELISA Kit
KLK5 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL012456HU | Human Kallikrein-5(KLK5) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates, saliva | 15.6 pg/mL |
