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KLK3

KLK3全稱為激肽釋放酶相關肽酶3,又稱前列腺特異性抗原(PSA),是人體精液中的重要成分。該蛋白由前列腺上皮細胞分泌,主要功能是通過分解精囊凝固蛋白促進精子液化,在生殖過程中起關鍵作用。KLK3表達受雄激素嚴格調控,臨床上常作為前列腺癌篩查的核心生物標志物。當血清PSA水平異常升高時,常提示前列腺增生、炎癥或惡性腫瘤可能,但需結合直腸指檢、影像學檢查綜合判斷。
PSA可通過裂解胰島素樣生長因子結合蛋白(IGFBP)影響細胞增殖通路,與腫瘤轉移存在潛在關聯。基于該蛋白特性開發的診斷試劑已廣泛應用于前列腺癌早期檢測,全球年檢測量超過1億人次。治療領域,靶向PSA的放射性核素療法(如177Lu-PSMA)在晚期前列腺癌患者中展現出顯著療效,目前FDA已批準Pluvicto?等藥物上市。我國自主研發的PSA抑制劑也進入Ⅱ期臨床試驗階段。

熱銷產品

KLK3 Recombinant Monoclonal Antibody (CSB-RA548583A0HU)

驗證數據

CSB-RA548583A0HU

IHC image of CSB-RA548583A0HU diluted at 1:100 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

KLK3 Antibodies

KLK3 for Homo sapiens (Human)

KLK3 ELISA Kit

KLK3 ELISA Kit for Homo sapiens (Human)