KCNN4
KCNN4，全稱為Intermediate conductance calcium-activated potassium channel protein 4，常見(jiàn)別名包括SKCa 4、SKCa4、rSK4等。該蛋白屬于鉀離子通道，能夠介導(dǎo)細(xì)胞膜上鉀離子的電壓非依賴性轉(zhuǎn)移。KCNN4蛋白的激活依賴于細(xì)胞內(nèi)鈣離子的濃度增加，其激活后能夠引起細(xì)胞膜超極化，進(jìn)而促進(jìn)鈣離子的內(nèi)流。KCNN4蛋白在多種生理過(guò)程中發(fā)揮重要作用，包括血管收縮、神經(jīng)細(xì)胞興奮性調(diào)節(jié)、細(xì)胞體積穩(wěn)態(tài)維持等。研究表明，KCNN4蛋白與多種疾病密切相關(guān)，如高血壓、心律失常、神經(jīng)退行性疾病等。目前，針對(duì)KCNN4蛋白的藥物研發(fā)已取得一定進(jìn)展，例如，有研究開(kāi)發(fā)了一種能夠抑制KCNN4蛋白活性的小分子化合物，該化合物在治療高血壓和心律失常方面展現(xiàn)出良好的前景。此外，KCNN4蛋白還被認(rèn)為是自身免疫性疾病的潛在治療靶點(diǎn)，相關(guān)藥物研發(fā)也在進(jìn)行中。
熱銷(xiāo)產(chǎn)品
驗(yàn)證數(shù)據(jù)
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-CF012086HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) KCNN4.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-CF012086HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) KCNN4.
KCNN4 Antibody (CSB-PA012086ESR2HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: KCNN4 antibody at 8µg/ml + human serum
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 48 kDa
Observed band size: 48 kDa
Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA012086ESR2HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA012086ESR2HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA012086ESR2HU at dilution of 1:100
KCNN4 Antibodies
KCNN4 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA012086ESR1HU | KCNN4 Antibody | Human | ELISA, IHC |
| CSB-PA012086ESR2HU | KCNN4 Antibody | Human | ELISA, WB, IHC |
| CSB-PA009613 | KCNN4 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA484256 | KCNN4 Antibody | Human | ELISA,IHC |
| CSB-PA980762 | KCNN4 Antibody | Human,Mouse | ELISA,WB,IHC |
KCNN4 Proteins
KCNN4 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP012086HU1 CSB-EP012086HU1 CSB-BP012086HU1 CSB-MP012086HU1 CSB-EP012086HU1-B |
Recombinant Human Intermediate conductance calcium-activated potassium channel protein 4 (KCNN4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF012086HU | Recombinant Human Intermediate conductance calcium-activated potassium channel protein 4 (KCNN4) | in vitro E.coli expression system |
| CSB-MP012086HU | Recombinant Human Intermediate conductance calcium-activated potassium channel protein 4 (KCNN4)-VLPs | Mammalian cell |
KCNN4 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP012086MO1 CSB-EP012086MO1 CSB-BP012086MO1 CSB-MP012086MO1 CSB-EP012086MO1-B |
Recombinant Mouse Intermediate conductance calcium-activated potassium channel protein 4 (Kcnn4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF012086MO | Recombinant Mouse Intermediate conductance calcium-activated potassium channel protein 4 (Kcnn4) | in vitro E.coli expression system |
KCNN4 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP886190RA1 CSB-EP886190RA1 CSB-BP886190RA1 CSB-MP886190RA1 CSB-EP886190RA1-B |
Recombinant Rat Intermediate conductance calcium-activated potassium channel protein 4 (Kcnn4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF886190RA | Recombinant Rat Intermediate conductance calcium-activated potassium channel protein 4 (Kcnn4) | in vitro E.coli expression system |
