ITPRIPL1
ITPRIPL1，全稱為Inositol 1,4,5-Triphosphate Receptor Interacting Protein-Like 1，常見別名包括ITPRIP like 1、inositol 1,4,5-trisphosphate receptor interacting protein-like 1等。該蛋白參與調(diào)節(jié)內(nèi)質(zhì)網(wǎng)中的鈣釋放，其表達(dá)與多種疾病相關(guān)，如脊髓小腦共濟(jì)失調(diào)15型等。研究表明，ITPRIPL1作為CD3ε的抑制配體，能夠抑制T細(xì)胞的活化，從而促進(jìn)腫瘤的免疫逃逸。這一發(fā)現(xiàn)為腫瘤免疫治療提供了新的靶點(diǎn)，相關(guān)抗體已進(jìn)入臨床研究階段。此外，ITPRIPL1的表達(dá)也可能與睪丸免疫豁免有關(guān)，其在睪丸中的高表達(dá)有助于維持免疫系統(tǒng)的平衡。目前，針對(duì)ITPRIPL1的藥物研發(fā)正在積極進(jìn)行中，有望為腫瘤治療和免疫調(diào)節(jié)領(lǐng)域帶來(lái)新的突破。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human ITPRIPL1 at 2 μg/ml can bind Anti-ITPRIPL1 recombinant antibody (CSB-RA756966MA1HU). The EC50 is 6.537-7.663 ng/mL.
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis ITPRIPL1 at 2 μg/ml can bind Anti-ITPRIPL1 recombinant antibody (CSB-RA756966MA1HU). The EC50 is 3.759-4.428 ng/mL.
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Mouse Itpripl1 at 2 μg/ml can bind Anti-ITPRIPL1 recombinant antibody (CSB-RA756966MA1HU). The EC50 is 0.7534-0.9877 ng/mL.
ITPRIPL1 Recombinant Monoclonal Antibody (CSB-RA756966MA1HU)
驗(yàn)證數(shù)據(jù)
The Binding Activity of Macaca fascicularis ITPRIPL1 with Anti-ITPRIPL1 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis ITPRIPL1 (CSB-MP6125MOV) at 2 μg/mL can bind Anti-ITPRIPL1 recombinant antibody. The EC50 is 3.759-4.428 ng/mL.
The Binding Activity of Human ITPRIPL1 with Anti-ITPRIPL1 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ITPRIPL1 (CSB-MP756966HU) at 2 μg/mL can bind Anti-ITPRIPL1 recombinant antibody. The EC50 is 6.537-7.663 ng/mL.
The Binding Activity of Mouse Itpripl1 with Anti-ITPRIPL1 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse Itpripl1 (CSB-MP011916MO1) at 2 μg/mL can bind Anti-ITPRIPL1 recombinant antibody. The EC50 is 0.7534-0.9877 ng/mL.
ITPRIPL1 Antibodies
ITPRIPL1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-RA756966MA1HU | ITPRIPL1 Recombinant Monoclonal Antibody | Human, Macaca fascicularis | ELISA |
ITPRIPL1 Proteins
ITPRIPL1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP756966HU CSB-EP756966HU CSB-BP756966HU CSB-EP756966HU-B |
Recombinant Human Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 (ITPRIPL1), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP756966HU | Recombinant Human Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 (ITPRIPL1), partial (Active) | Mammalian cell |
