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ITM2B

ITM2B,全稱為整合膜蛋白2B,常用別名是BRI2。它是一種跨膜蛋白,在人體多種組織中分布,其中神經(jīng)系統(tǒng)的神經(jīng)元是其主要表達場所。這種蛋白能與淀粉樣前體蛋白等分子結(jié)合,調(diào)控這些蛋白的加工過程,避免產(chǎn)生對神經(jīng)細胞有毒性的異常片段,維持神經(jīng)細胞正常功能。
當ITM2B基因發(fā)生突變時,BRI2蛋白功能異常,無法有效調(diào)控相關(guān)蛋白,進而引發(fā)家族性英國型癡呆和家族性丹麥型癡呆兩種罕見神經(jīng)退行性疾病,患者會出現(xiàn)認知下降、運動障礙等癥狀,與阿爾茨海默病部分表現(xiàn)相似。藥物研發(fā)方面,實驗室正探索通過小分子或肽類調(diào)節(jié)BRI2活性,以改善相關(guān)蛋白代謝異常,為這類疾病治療提供新思路,但目前研究多處于早期階段。

熱銷產(chǎn)品

ITM2B Antibody (CSB-PA011904LA01HU)

驗證數(shù)據(jù)

CSB-PA011904LA01HU

IHC image of CSB-PA011904LA01HU diluted at 1:400 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA011904LA01HU

IHC image of CSB-PA011904LA01HU diluted at 1:400 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA011904LA01HU

Immunofluorescence staining of Hela cells with CSB-PA011904LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

ITM2B Antibodies

ITM2B for Homo sapiens (Human)

ITM2B Proteins

ITM2B Proteins for Homo sapiens (Human)