IRF3
IRF3，全稱(chēng)為干擾素調(diào)節(jié)因子3，是一種在免疫反應(yīng)中發(fā)揮重要作用的轉(zhuǎn)錄調(diào)節(jié)因子。它能夠識(shí)別病毒感染或其他病原體入侵的信號(hào)，并激活下游的信號(hào)通路，從而促進(jìn)抗病毒免疫反應(yīng)的發(fā)生。IRF3蛋白在未感染的細(xì)胞中處于非活性狀態(tài)，但在病毒感染后，它會(huì)發(fā)生磷酸化修飾，進(jìn)而形成二聚體并轉(zhuǎn)移到細(xì)胞核中，與DNA結(jié)合并調(diào)控下游基因的轉(zhuǎn)錄。IRF3蛋白能夠識(shí)別多種病毒感染的信號(hào)，包括DNA病毒和RNA病毒，從而激活I(lǐng)型干擾素的產(chǎn)生，增強(qiáng)細(xì)胞的抗病毒能力。此外，IRF3蛋白還參與調(diào)控炎癥反應(yīng)和細(xì)胞凋亡等過(guò)程。研究表明，IRF3蛋白與多種疾病的發(fā)生發(fā)展密切相關(guān)，包括病毒感染、自身免疫性疾病和腫瘤等。因此，IRF3蛋白成為抗病毒藥物研發(fā)的重要靶點(diǎn)。目前，針對(duì)IRF3蛋白的抑制劑已被開(kāi)發(fā)用于治療病毒感染和自身免疫性疾病。
熱銷(xiāo)產(chǎn)品
Recombinant Human Interferon regulatory factor 3 (IRF3) (CSB-EP011818HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
IRF3 Recombinant Monoclonal Antibody (CSB-RA442967A0HU)
驗(yàn)證數(shù)據(jù)
Flow cytometric analysis of Interferon regulatory factor 3 expression in HepG2 cells using Interferon regulatory factor 3 antibody. Green, isotype control; red, Interferon regulatory factor 3.
Immunocytochemical staining of HepG2 cells with Interferon regulatory factor 3 antibody. Nuclei were stained blue with DAPI; Interferon regulatory factor 3 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Low. Scale bar: 20 μm.
Western blotting analysis using Interferon regulatory factor 3 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with Interferon regulatory factor 3 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
驗(yàn)證數(shù)據(jù)
Western blot analysis of hela Cell Lysate, antibody was diluted at 1:1000. Secondary antibody was diluted at 1:20000
Immunohistochemical analysis of paraffin-embedded human-tonsils, antibody was diluted at 1:200
Immunohistochemical analysis of paraffin-embedded human-kidney, antibody was diluted at 1:200
IRF3 Antibodies
IRF3 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA011818GA01HU | IRF3 Antibody | Human | ELISA,WB,IHC,IF |
| CSB-PA029024 | Phospho-IRF3 (Ser386) Antibody | Human | ELISA,WB |
| CSB-PA003063 | IRF3 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA011238 | Phospho-IRF3 (S396) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA011239 | Phospho-IRF3 (S386) Antibody | Human | WB, ELISA |
| CSB-PA011240 | Phospho-IRF3 (S385) Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA011241 | IRF3 Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA011242 | IRF3 Antibody | Human | WB, IHC, ELISA |
| CSB-PA572418 | IRF3 Antibody | Human | ELISA,IHC |
| CSB-PA283183 | IRF3 Antibody | Human | ELISA,WB,IHC |
| CSB-PA510322 | IRF3 Antibody | Human | IHC,ELISA |
| CSB-PA952191 | IRF3 Antibody | Human | IHC,ELISA |
| CSB-RA011818A386phHU | Phospho-IRF3 (S386) Recombinant Monoclonal Antibody | Human | ELISA, WB |
| CSB-RA442967A0HU | IRF3 Recombinant Monoclonal Antibody | Human | ELISA, WB, FC, ICC |
IRF3 for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA011818YA01MO | Irf3 Antibody | Mouse | ELISA |
| CSB-PA011818YB01MO | Irf3 Antibody, HRP conjugated | Mouse | ELISA |
| CSB-PA011818YD01MO | Irf3 Antibody, Biotin conjugated | Mouse | ELISA |
IRF3 Proteins
IRF3 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP011818MO | Recombinant Mouse Interferon regulatory factor 3 (Irf3) | Yeast |
| CSB-EP011818MO | Recombinant Mouse Interferon regulatory factor 3 (Irf3) | E.coli |
| CSB-BP011818MO CSB-MP011818MO CSB-EP011818MO-B |
Recombinant Mouse Interferon regulatory factor 3 (Irf3) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IRF3 Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP011818PI CSB-EP011818PI CSB-BP011818PI CSB-MP011818PI CSB-EP011818PI-B |
Recombinant Pig Interferon regulatory factor 3 (IRF3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IRF3 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP011818CH CSB-EP011818CH CSB-BP011818CH CSB-MP011818CH CSB-EP011818CH-B |
Recombinant Chicken Interferon regulatory factor 3 (IRF3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IRF3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP011818HU CSB-BP011818HU CSB-MP011818HU CSB-EP011818HU-B |
Recombinant Human Interferon regulatory factor 3 (IRF3) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP011818HU | Recombinant Human Interferon regulatory factor 3 (IRF3) | E.coli |
IRF3 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP011818BO CSB-EP011818BO CSB-BP011818BO CSB-MP011818BO CSB-EP011818BO-B |
Recombinant Bovine Interferon regulatory factor 3 (IRF3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
