Inversin是人體中由INVS基因編碼的一種蛋白質(zhì)。它在正常腎臟發(fā)育和左右軸的建立中起著必要作用。可能作為不同Wnt信號(hào)通路之間的分子開(kāi)關(guān)。通過(guò)靶向細(xì)胞質(zhì)中的Disheveled（DVL1）使其被泛素蛋白酶降解，從而抑制了經(jīng)典Wnt通路。這表明，在腎臟發(fā)育中，它在對(duì)抗Wnt信號(hào)抑制小管上皮細(xì)胞末期分化方面是必要的。與NPHP1、NPHP4和RPGRIP1L/NPHP8（類(lèi)似物）共同參與調(diào)節(jié)腎細(xì)胞頂部結(jié)合的組織。似乎不是纖毛發(fā)生的嚴(yán)格必需品（類(lèi)似）。

Inversin is a protein in humans that is encoded by INVS gene. Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity).