IL10RA
白細(xì)胞介素10受體α亞基（IL10RA）是調(diào)控免疫穩(wěn)態(tài)的關(guān)鍵膜蛋白，也被稱為CDW210A或IL-10R1。它通過與細(xì)胞因子IL-10特異性結(jié)合，抑制促炎因子釋放，維持機(jī)體炎癥與抗炎反應(yīng)的動態(tài)平衡。IL10RA在巨噬細(xì)胞、T淋巴細(xì)胞等免疫細(xì)胞表面廣泛表達(dá)，其功能缺陷可能導(dǎo)致嬰兒期炎癥性腸病、極早發(fā)型克羅恩病等遺傳性腸道病變。近年來，科研人員發(fā)現(xiàn)IL10RA基因突變與部分原發(fā)性免疫缺陷綜合征密切相關(guān)，這類患者常表現(xiàn)為反復(fù)感染或組織損傷。在藥物開發(fā)領(lǐng)域，基于IL-10信號通路的新型生物制劑已進(jìn)入臨床研究階段，部分候選藥物在銀屑病、類風(fēng)濕關(guān)節(jié)炎等自身免疫性疾病中展現(xiàn)出調(diào)節(jié)過度免疫反應(yīng)的潛力。此外，針對受體結(jié)構(gòu)的分子優(yōu)化策略正在探索，旨在提高IL-10類似物的靶向性和穩(wěn)定性。
熱銷產(chǎn)品
Recombinant Human Interleukin-10 receptor subunit alpha (IL10RA), partial (CSB-MP621688HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
IL10RA Antibody (CSB-PA621688ESR2HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: Interleukin-10 receptor subunit alpha antibody at 8μg/ml
Lane 1: Mouse heart tissue
Lane 2: Hela whole cell lysate
Lane 3: Mouse liver tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 63 kDa
Observed band size: 63 kDa
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA621688ESR2HU at dilution of 1:100
IL10RA Antibodies
IL10RA for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA011581GA01HU | IL10RA Antibody | Human | ELISA,WB |
| CSB-PA621688ESR2HU | IL10RA Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA949178 | Phospho-IL10RA (Ser319/323) Antibody | Human | ELISA,WB |
| CSB-PA051687 | Phospho-IL10RA (Tyr496) Antibody | Human | ELISA,WB |
| CSB-PA003017 | IL10RA Antibody | Human | WB, IF, ELISA |
| CSB-PA006290 | IL10RA Antibody | Human | WB, ELISA |
| CSB-PA009575 | Phospho-IL10RA (Y496) Antibody | Human | WB, ELISA |
| CSB-PA062287 | IL10RA Antibody | Human | ELISA,IHC |
| CSB-PA153938 | IL10RA Antibody | Human | ELISA,IHC |
| CSB-PA621688EA01HU | IL10RA Antibody | Human | ELISA, WB, IF |
| CSB-PA621688EB01HU | IL10RA Antibody, HRP conjugated | Human | ELISA |
| CSB-PA621688EC01HU | IL10RA Antibody, FITC conjugated | Human | |
| CSB-PA621688ED01HU | IL10RA Antibody, Biotin conjugated | Human | ELISA |
IL10RA Proteins
IL10RA Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-EP621688HU CSB-BP621688HU CSB-EP621688HU-B |
Recombinant Human Interleukin-10 receptor subunit alpha (IL10RA), partial | E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-YP621688HU | Recombinant Human Interleukin-10 receptor subunit alpha (IL10RA), partial | Yeast |
| CSB-MP621688HU | Recombinant Human Interleukin-10 receptor subunit alpha (IL10RA), partial | Mammalian cell |
| CSB-MP621688HU(A5)(M) | Recombinant Human Interleukin-10 receptor subunit alpha (IL10RA) (3-6: PCLV→GCVL)-VLPs | Mammalian cell |
| CSB-MP621688HUd7 | Recombinant Human Interleukin-10 receptor subunit alpha (IL10RA), partial | Mammalian cell |
IL10RA Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP720259MO CSB-EP720259MO CSB-BP720259MO CSB-MP720259MO CSB-EP720259MO-B |
Recombinant Mouse Interleukin-10 receptor subunit alpha (Il10ra), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL10RA ELISA Kit
IL10RA ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL011581MO | Mouse Interleukin-10 receptor subunit alpha(IL10RA) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 0.078 ng/mL |
