IKZF3

IKZF3，即IKAROS家族鋅指蛋白3，別名AIO、IMD84、AIOLOS、ZNFN1A3。IKZF3作為轉(zhuǎn)錄因子，通過(guò)其鋅指結(jié)構(gòu)域與DNA結(jié)合，參與淋巴細(xì)胞的發(fā)育和調(diào)節(jié)B淋巴細(xì)胞的增殖和分化。IKZF3能夠參與染色質(zhì)重塑，形成Ikaros同二聚體、Ikaros/Aiolos異二聚體和Aiolos同二聚體，從而調(diào)節(jié)基因表達(dá)。IKZF3在多種造血和免疫細(xì)胞中發(fā)揮多效性作用，尤其在B淋巴細(xì)胞的分化和成熟中占主導(dǎo)地位，介導(dǎo)激活B淋巴細(xì)胞對(duì)刺激的反應(yīng)和B細(xì)胞增殖。IKZF3的功能紊亂與惡性腫瘤、自身免疫病和免疫缺陷等多種疾病的病理過(guò)程相關(guān)，其在多發(fā)性骨髓瘤中過(guò)度表達(dá)，導(dǎo)致惡性漿細(xì)胞的大量增殖。

熱銷產(chǎn)品

IKZF3 Antibody (CSB-PA892336DSR1HU)

驗(yàn)證數(shù)據(jù)

Western blot
All lanes: Zinc finger protein Aiolos antibody at 8μg/ml + HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 59, 52, 54, 30, 48, 50, 55, 42, 36, 33, 43, 31 kDa
Observed band size: 59 kDa

Human Zinc finger protein Aiolos(IKZF3) ELISA kit (CSB-EL011577HU)

驗(yàn)證數(shù)據(jù)

貨號(hào)：CSB-EL011577HU

規(guī)格：96T/48T

靈敏度：6.25 pg/mL

檢測(cè)范圍：25 pg/mL-1600 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

IKZF3 Antibody

IKZF3 Protein

IKZF3 ELISA Kit

IKZF3 Antibodies

IKZF3 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA011577GA01HU	IKZF3 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA892336DSR1HU	IKZF3 Antibody	Human	ELISA, WB
CSB-PA970658	IKZF3 Antibody	Human,Mouse	ELISA,WB
CSB-PA003007	IKZF3 Antibody	Human,Mouse	WB, ELISA
CSB-PA192244	IKZF3 Antibody	Human,Mouse	ELISA,IHC
CSB-PA577111	IKZF3 Antibody	Human,Mouse	ELISA,IHC

IKZF3 Proteins

IKZF3 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP892336HU CSB-EP892336HU CSB-BP892336HU CSB-MP892336HU CSB-EP892336HU-B	Recombinant Human Zinc finger protein Aiolos (IKZF3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli