IGHE，即免疫球蛋白重鏈ε（IgE），屬于免疫球蛋白超家族成員。該蛋白主要參與過(guò)敏反應(yīng)和抗寄生蟲(chóng)免疫。IgE蛋白作為B細(xì)胞上的膜結(jié)合受體，在特異性抗原結(jié)合后觸發(fā)B細(xì)胞的克隆擴(kuò)增和分化為漿細(xì)胞，進(jìn)而分泌IgE抗體。IgE抗體與肥大細(xì)胞和嗜堿性粒細(xì)胞表面的高親和力FcεRI受體結(jié)合，觸發(fā)組胺等炎癥介質(zhì)的釋放，導(dǎo)致過(guò)敏反應(yīng)的發(fā)生。此外，IgE蛋白還在抗寄生蟲(chóng)免疫中發(fā)揮作用，通過(guò)與寄生蟲(chóng)表面的抗原結(jié)合，激活嗜酸性粒細(xì)胞等免疫細(xì)胞，清除寄生蟲(chóng)。
IGHE與多種過(guò)敏性疾病相關(guān)，如特應(yīng)性皮炎、哮喘、蕁麻疹等。此外，IGHE蛋白的低表達(dá)可能增加寄生蟲(chóng)感染的風(fēng)險(xiǎn)。目前，針對(duì)IGHE蛋白的藥物研發(fā)主要集中在過(guò)敏性疾病的治療上。例如，一些藥物可以抑制IgE抗體的產(chǎn)生或阻止IgE與FcεRI受體的結(jié)合，從而減輕過(guò)敏反應(yīng)的癥狀。此外，還有一些藥物可以增強(qiáng)IgE介導(dǎo)的抗寄生蟲(chóng)免疫，用于治療寄生蟲(chóng)感染。

熱銷產(chǎn)品

Recombinant Human Immunoglobulin heavy constant epsilon (IGHE), partial (Active) (CSB-MP1684HU3d7)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human IGHE at 2 μg/ml can bind Anti-IGHE recombinant antibody (CSB-RA16849MA1HU). The EC₅₀ is 3.097-4.487 ng/mL.

IGHE (Ligelizumab) Recombinant Monoclonal Antibody (CSB-RA16849MA1HU)

驗(yàn)證數(shù)據(jù)

The Binding Activity of Human IGHE with Anti-IGHE Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human IGHE (CSB-MP1684HU3d7) at 2 μg/mL can bind Anti-IGHE recombinant antibody. The EC₅₀ is 3.097-4.487 ng/mL.