IGFLR1
IGFR1是胰島素樣生長(zhǎng)因子1受體，也稱為IGF-1R。它是一種細(xì)胞表面受體，在細(xì)胞生長(zhǎng)、增殖和存活中發(fā)揮重要作用。IGFR1通過胰島素樣生長(zhǎng)因子1（IGF-1）和胰島素樣生長(zhǎng)因子2（IGF-2）這兩種肽類激素來激活。 當(dāng)IGF-1或IGF-2與IGFR1結(jié)合時(shí)，會(huì)觸發(fā)一個(gè)信號(hào)級(jí)聯(lián)，促進(jìn)細(xì)胞分裂、生長(zhǎng)和分化。這個(gè)受體在發(fā)育過程中以及成年后的組織維護(hù)中都至關(guān)重要。然而，IGF-1R信號(hào)通路的失調(diào)可能與多種疾病相關(guān)，包括癌癥。 在癌癥研究中，IGFR1已被研究為癌癥治療的潛在靶點(diǎn)。抑制IGFR1的活性可以是減緩癌細(xì)胞生長(zhǎng)和減少腫瘤進(jìn)展的策略。了解IGFR1的結(jié)構(gòu)和功能對(duì)于在腫瘤學(xué)領(lǐng)域開發(fā)有針對(duì)性的治療方法至關(guān)重要。
熱銷產(chǎn)品
● Recombinant Human IGF-like family receptor 1(IGFLR1),partial (Active) CSB-MP862025HUd9
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human IGFLR1 at 2 μg/ml can bind Human IGFL1 (CSB-MP764932HUh8), the EC50 is 4.640-5.722 ng/mL.
● Recombinant Human IGF-like family receptor 1(IGFLR1),partial (Active) CSB-MP862025HU
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human IGFLR1 at 2 μg/ml can bind Human IGFL1 (CSB-MP764932HU), the EC50 is 32.33-47.52 ng/mL.
IGFLR1 Proteins
IGFLR1 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP023719BO1 CSB-EP023719BO1 CSB-BP023719BO1 CSB-MP023719BO1 CSB-EP023719BO1-B |
Recombinant Bovine IGF-like family receptor 1 (IGFLR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF023719BO | Recombinant Bovine IGF-like family receptor 1 (IGFLR1) | in vitro E.coli expression system |
IGFLR1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP663649MO CSB-BP663649MO CSB-EP663649MO-B |
Recombinant Mouse IGF-like family receptor 1 (Igflr1), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP663649MO | Recombinant Mouse IGF-like family receptor 1 (Igflr1), partial | E.coli |
| CSB-MP663649MO | Recombinant Mouse IGF-like family receptor 1 (Igflr1), partial | Mammalian cell |
| CSB-MP663649MOd7 | Recombinant Mouse IGF-like family receptor 1 (Igflr1), partial | Mammalian cell |
IGFLR1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP862025HU CSB-EP862025HU CSB-BP862025HU CSB-EP862025HU-B |
Recombinant Human IGF-like family receptor 1 (IGFLR1), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP862025HUd9 | Recombinant Human IGF-like family receptor 1 (IGFLR1), partial (Active) | Mammalian cell |
| CSB-MP862025HU | Recombinant Human IGF-like family receptor 1 (IGFLR1), partial (Active) | Mammalian cell |
