IFNAR2

IFNAR2，全稱為干擾素α和β受體亞基2，是一種I型膜蛋白，與IFNAR1共同構(gòu)成干擾素α和β受體的兩條鏈。該蛋白屬于II型細胞因子受體家族，其作用機制是通過與干擾素結(jié)合，激活JAK-STAT信號通路，進而磷酸化多種蛋白質(zhì)，包括STAT1和STAT2，從而引發(fā)一系列細胞反應(yīng)。IFNAR2在多種組織中表達，包括泌尿生殖系統(tǒng)、淋巴系統(tǒng)、肝臟和神經(jīng)系統(tǒng)。IFNAR2與乙型肝炎和免疫缺陷45相關(guān)，其突變可能導(dǎo)致免疫缺陷疾病。目前，針對IFNAR2的藥物研發(fā)主要集中在利用其作為穩(wěn)定劑來提高干擾素制劑的穩(wěn)定性和效力，例如開發(fā)長效干擾素制劑。此外，IFNAR2也被用作治療自身免疫性疾病的靶點，例如阿斯利康的治療紅斑狼瘡新藥Saphnelo（anifrolumab）就是一種I型干擾素拮抗劑，可與IFNAR2結(jié)合，拮抗所有I型干擾素的相關(guān)活性。

熱銷產(chǎn)品

Recombinant Human Interferon alpha/beta receptor 2 (IFNAR2), partial (CSB-MP011047HU)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

The purity of IFNAR2 was greater than 95% as determined by SEC-HPLC

IFNAR2 Antibody (CSB-PA011047ESR2HU)

驗證數(shù)據(jù)

Western blot
All lanes: IFNAR2 antibody at 10µg/ml + MCF-7 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 58, 38, 28 kDa
Observed band size: 58 kDa

Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA011047ESR2HU at dilution of 1:100

IFNAR2 Antibody

IFNAR2 Protein

IFNAR2 ELISA Kit

IFNAR2 Antibodies

IFNAR2 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA011047GA01HU	IFNAR2 Antibody	Human	ELISA,WB
CSB-PA011047ESR1HU	IFNAR2 Antibody	Human	ELISA, IHC
CSB-PA011047ESR2HU	IFNAR2 Antibody	Human	ELISA, WB, IHC
CSB-PA11439A0Rb	IFNAR2 Antibody	Human	ELISA, IHC
CSB-PA11439D0Rb	IFNAR2 Antibody, Biotin conjugated	Human	ELISA
CSB-PA005590	IFNAR2 Antibody	Human	WB, ELISA

IFNAR2 Proteins

IFNAR2 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP011047HU CSB-BP011047HU CSB-EP011047HU-B	Recombinant Human Interferon alpha/beta receptor 2 (IFNAR2), partial	Yeast Baculovirus In Vivo Biotinylation in E.coli
CSB-EP011047HU	Recombinant Human Interferon alpha/beta receptor 2 (IFNAR2), partial	E.coli
CSB-CF011047HU(A4)	Recombinant Human Interferon alpha/beta receptor 2 (IFNAR2)	in vitro E.coli expression system

IFNAR2 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP011047MO	Recombinant Mouse Interferon alpha/beta receptor 2 (Ifnar2), partial	Yeast
CSB-EP011047MO CSB-BP011047MO CSB-MP011047MO CSB-EP011047MO-B	Recombinant Mouse Interferon alpha/beta receptor 2 (Ifnar2), partial	E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IFNAR2 Proteins for Ovis aries (Sheep)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP850133SH CSB-EP850133SH CSB-BP850133SH CSB-MP850133SH CSB-EP850133SH-B	Recombinant Sheep Interferon alpha/beta receptor 2 (IFNAR2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IFNAR2 Proteins for Bos taurus (Bovine)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP856764BO CSB-EP856764BO CSB-BP856764BO CSB-MP856764BO CSB-EP856764BO-B	Recombinant Bovine Interferon alpha/beta receptor 2 (IFNAR2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli