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HTT

HTT,全稱為亨廷頓蛋白,是一種廣泛表達于人體各器官的蛋白質,尤其在腦部中起重要作用。該蛋白的正常功能尚未完全明確,但研究表明其可能參與神經系統發育、細胞內吞和分泌以及抑制細胞凋亡等過程。HTT蛋白的異常變異會導致亨廷頓舞蹈癥,這是一種遺傳性神經退行性疾病,其特征是機體運動和認知功能的進行性障礙或紊亂。亨廷頓舞蹈癥由HTT基因第一個外顯子CAG序列的重復擴增引起,導致亨廷頓蛋白的多聚谷氨酰胺束延長,從而引發蛋白質聚集和神經變性。
針對亨廷頓舞蹈癥的藥物研發主要集中在抑制HTT蛋白的聚集和改善神經元功能等方面,例如輝大基因開發的基于Cas12Max的基因編輯療法,旨在降低HTT蛋白的表達水平,從而緩解疾病癥狀。此外,抗亨廷頓蛋白抗體和RNA干擾技術也被探索用于治療亨廷頓舞蹈癥。盡管目前尚無根治方法,但這些研究進展為未來治療提供了新的希望。

熱銷產品

HTT Recombinant Monoclonal Antibody (CSB-RA802195A0HU)

驗證數據

CSB-RA802195A0HU

IHC image of CSB-RA802195A0HU diluted at 1:100 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA802195A0HU

IHC image of CSB-RA802195A0HU diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Human Huntingtin(HTT) ELISA kit (CSB-EL010905HU)

驗證數據

CSB-EL010905HU 標準曲線

貨號:CSB-EL010905HU

規格:96T/48T

靈敏度:3.125 pg/mL

檢測范圍:12.5 pg/mL-800 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

HTT Antibodies

HTT for Homo sapiens (Human)

HTT Proteins

HTT Proteins for Homo sapiens (Human)

HTT ELISA Kit

HTT ELISA Kit for Homo sapiens (Human)



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