HIPK2
HIPK2，即同源結(jié)構(gòu)域相互作用蛋白激酶2，別名PRO0593、hHIPk2。HIPK2是一種絲氨酸/蘇氨酸激酶，屬于同源結(jié)構(gòu)域相互作用蛋白激酶家族。HIPK2與同源結(jié)構(gòu)域轉(zhuǎn)錄因子和許多其他轉(zhuǎn)錄因子（如p53）相互作用，可以根據(jù)轉(zhuǎn)錄因子及其亞細(xì)胞定位同時(shí)充當(dāng)共抑制因子和共激活因子。HIPK2可以誘導(dǎo)或抑制轉(zhuǎn)錄，調(diào)節(jié)細(xì)胞分化、增殖及凋亡。HIPK2經(jīng)過(guò)泛素化、小泛素樣修飾（SUMO）化、乙酰化、磷酸化等翻譯后修飾來(lái)發(fā)揮其生物功能。HIPK2能促進(jìn)細(xì)胞凋亡，是潛在的腫瘤抑制因子和DNA損傷相關(guān)激酶，通過(guò)磷酸化反應(yīng)作用于不同的下游靶點(diǎn)來(lái)激活凋亡進(jìn)程。HIPK2還參與組織器官的形成、腫瘤的發(fā)生和發(fā)展。
熱銷(xiāo)產(chǎn)品
HIPK2 Antibody (CSB-PA867138LA01HU)
驗(yàn)證數(shù)據(jù)
IHC image of CSB-PA867138LA01HU diluted at 1:500 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of CSB-PA867138LA01HU diluted at 1:500 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
HIPK2 Antibodies
HIPK2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA867138LA01HU | HIPK2 Antibody | Human | ELISA, IHC |
| CSB-PA867138LB01HU | HIPK2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA867138LC01HU | HIPK2 Antibody, FITC conjugated | Human | |
| CSB-PA867138LD01HU | HIPK2 Antibody, Biotin conjugated | Human | ELISA |
HIPK2 Proteins
HIPK2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP867138HU CSB-EP867138HU CSB-BP867138HU CSB-MP867138HU CSB-EP867138HU-B |
Recombinant Human Homeodomain-interacting protein kinase 2 (HIPK2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HIPK2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP882585MO CSB-EP882585MO CSB-BP882585MO CSB-MP882585MO CSB-EP882585MO-B |
Recombinant Mouse Homeodomain-interacting protein kinase 2 (Hipk2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HIPK2 Proteins for Mesocricetus auratus (Golden hamster)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP895752MRG CSB-EP895752MRG CSB-BP895752MRG CSB-MP895752MRG CSB-EP895752MRG-B |
Recombinant Mesocricetus auratus Homeodomain-interacting protein kinase 2 (Hipk2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
