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HDAC3

HDAC3,即組蛋白去乙酰化酶3,別名HD3、Histone deacetylase 3、RPD3-2、SMAP45。它是一種由HDAC3基因編碼的酶,屬于I類組蛋白去乙酰化酶家族成員,在多種細(xì)胞類型中廣泛表達(dá)。HDAC3的作用機(jī)制主要是通過(guò)去除組蛋白和非組蛋白上的乙酰基團(tuán),調(diào)控染色質(zhì)結(jié)構(gòu)和基因表達(dá),參與細(xì)胞增殖、分化、遷移和凋亡等過(guò)程。HDAC3參與調(diào)節(jié)多種細(xì)胞生命活動(dòng),包括細(xì)胞周期控制、細(xì)胞應(yīng)激反應(yīng)、代謝調(diào)控等。此外,HDAC3的功能異常與某些疾病有關(guān),如癌癥、神經(jīng)退行性疾病等,是藥物開(kāi)發(fā)和疾病治療中的潛在靶點(diǎn)。

熱銷產(chǎn)品

Recombinant Human Histone deacetylase 3 (HDAC3) (CSB-EP010239HU)

驗(yàn)證數(shù)據(jù)

CSB-EP010239HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

HDAC3 Recombinant Monoclonal Antibody (CSB-RA906662A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA906662A0HU

Western Blot
Positive WB detected in: Hela whole cell lysate, HL60 whole cell lysate, U251 whole cell lysate, K562 whole cell lysate, 293T whole cell lysate
All lanes: HDAC3 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 49, 50 kDa
Observed band size: 49 kDa

CSB-RA906662A0HU

IHC image of CSB-RA906662A0HU diluted at 1:100 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA906662A0HU

IHC image of CSB-RA906662A0HU diluted at 1:100 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

HDAC3 Antibodies

HDAC3 for Homo sapiens (Human)

HDAC3 Proteins

HDAC3 Proteins for Homo sapiens (Human)



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