GRM1

GRM1，全名為谷氨酸代謝型受體1（mGluR1），別名包括GPRC1A、MGLU1、MGLUR1等。該蛋白屬于谷氨酸受體家族，通過激活磷脂酶c發揮作用，參與神經遞質的傳遞和調節。GRM1蛋白與多種疾病相關，如脊髓小腦性共濟失調44（SCA44）和常染色體隱性小腦性共濟失調13（SCAR13）。SCA44是由新的de novo GRM1變異c.2303 C＞T（p.Thr768Ile）引起的，該變異通過增加mGluR1的組成性活性導致疾病。而SCAR13則與mGluR1功能喪失相關。在藥物研發方面，利魯唑等藥物被用于治療側索硬化癥，顯示出對mGluR1功能的調節作用。目前，針對GRM1蛋白的藥物研發仍在進行中，旨在恢復其正常功能，為相關疾病的治療提供新的思路。

熱銷產品

GRM1 Antibody (CSB-PA009931LA01HU)

驗證數據

Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA009931LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA009931LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

GRM1 Antibody

GRM1 Protein

GRM1 Antibodies

GRM1 for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA009931GA01HU	GRM1 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA009017	GRM1 Antibody	Human,Mouse,Rat	IHC, ELISA
CSB-PA054030	GRM1 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA559950	GRM1 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA009931LA01HU	GRM1 Antibody	Human	ELISA, IHC, IF
CSB-PA009931LB01HU	GRM1 Antibody, HRP conjugated	Human	ELISA
CSB-PA009931LC01HU	GRM1 Antibody, FITC conjugated	Human
CSB-PA009931LD01HU	GRM1 Antibody, Biotin conjugated	Human	ELISA

GRM1 Proteins

GRM1 Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP009931MO CSB-EP009931MO CSB-BP009931MO CSB-MP009931MO CSB-EP009931MO-B	Recombinant Mouse Metabotropic glutamate receptor 1 (Grm1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

GRM1 Proteins for Rattus norvegicus (Rat)

產品貨號	產品名稱	來源
CSB-YP009931RA CSB-EP009931RA CSB-BP009931RA CSB-MP009931RA CSB-EP009931RA-B	Recombinant Rat Metabotropic glutamate receptor 1 (Grm1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

GRM1 Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP615673HU CSB-EP615673HU CSB-BP615673HU CSB-MP615673HU CSB-EP615673HU-B	Recombinant Human Metabotropic glutamate receptor 1 (GRM1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli