GPR84
GPR84是一種G蛋白偶聯(lián)受體，即中鏈脂肪酸受體。它在多種細(xì)胞類型中表達(dá)，包括中性粒細(xì)胞等免疫細(xì)胞。GPR84的作用機(jī)制涉及通過與脂肪酸等配體結(jié)合，激活下游信號(hào)通路，影響細(xì)胞的遷移、脫顆粒和氧化應(yīng)激反應(yīng)。在信號(hào)傳導(dǎo)方面，GPR84能夠通過Lyn-AKT/ERK通路進(jìn)行信號(hào)轉(zhuǎn)導(dǎo)，進(jìn)而調(diào)控氧化應(yīng)激關(guān)鍵蛋白p47PHOX的活性，參與活性氧簇（ROS）的產(chǎn)生。在生物學(xué)意義上，GPR84參與調(diào)控炎癥反應(yīng)和免疫應(yīng)答，尤其在急性肺損傷（ALI）等疾病中發(fā)揮重要作用，其表達(dá)的變化與肺部炎癥因子水平、肺組織損傷程度密切相關(guān)。因此，GPR84被認(rèn)為是治療急性肺損傷等炎癥性疾病的潛在藥物靶點(diǎn)。
熱銷產(chǎn)品
Recombinant Human G-protein coupled receptor 84 (GPR84), partial (CSB-YP865107HU2)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
The purity of GPR84 was greater than 90% as determined by SEC-HPLC
GPR84 Antibody (CSB-PA865107LA01HU)
驗(yàn)證數(shù)據(jù)
Immunofluorescent analysis of Hela cells using CSB-PA865107LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
GPR84 Antibodies
GPR84 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA865107LA01HU | GPR84 Antibody | Human | ELISA, IF |
| CSB-PA865107LB01HU | GPR84 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA865107LC01HU | GPR84 Antibody, FITC conjugated | Human | |
| CSB-PA865107LD01HU | GPR84 Antibody, Biotin conjugated | Human | ELISA |
GPR84 Proteins
GPR84 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP644417BO1 CSB-EP644417BO1 CSB-BP644417BO1 CSB-MP644417BO1 CSB-EP644417BO1-B |
Recombinant Bovine G-protein coupled receptor 84 (GPR84), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF644417BO | Recombinant Bovine G-protein coupled receptor 84 (GPR84) | in vitro E.coli expression system |
GPR84 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP807541MO1 CSB-EP807541MO1 CSB-BP807541MO1 CSB-MP807541MO1 CSB-EP807541MO1-B |
Recombinant Mouse G-protein coupled receptor 84 (Gpr84), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF807541MO | Recombinant Mouse G-protein coupled receptor 84 (Gpr84) | in vitro E.coli expression system |
GPR84 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP865107HU1 CSB-EP865107HU1 CSB-BP865107HU1 CSB-MP865107HU1 CSB-EP865107HU1-B |
Recombinant Human G-protein coupled receptor 84 (GPR84), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF865107HU | Recombinant Human G-protein coupled receptor 84 (GPR84) | in vitro E.coli expression system |
| CSB-YP865107HU2 | Recombinant Human G-protein coupled receptor 84 (GPR84), partial | Yeast |
