GPNMB
跨膜糖蛋白GPNMB全稱為黑色素瘤非轉移性糖蛋白B，常被稱為骨激活素或樹突狀細胞相關跨膜蛋白。GPNMB廣泛分布于黑色素細胞、破骨細胞及免疫細胞表面，主要參與細胞間識別與微環(huán)境調控，其異常表達常伴隨腫瘤侵襲性增強和免疫逃逸現(xiàn)象。GPNMB在超過40%的三陰性乳腺癌和惡性黑色素瘤中過度活躍，其介導的促存活信號可能加速腫瘤轉移。在神經(jīng)退行性疾病領域，該蛋白與β淀粉樣蛋白存在相互作用，可能影響阿爾茨海默病的病理進程。目前全球有多款靶向GPNMB的藥物進入臨床階段，其中抗體偶聯(lián)藥物CDX-011在轉移性乳腺癌的Ⅱ期試驗中顯示出可控安全性，新型雙抗藥物GT-002則通過阻斷GPNMB與整合素結合來抑制骨肉瘤生長。某些小分子抑制劑已證實可穿透血腦屏障，為神經(jīng)相關疾病的治療開辟了新方向。
熱銷產(chǎn)品
GPNMB Recombinant Monoclonal Antibody (CSB-RA622928MA1HU)
驗證數(shù)據(jù)
Overlay Peak curve showing Hela cells stained with CSB-RA622928MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10, 003 events was performed.
Human Transmembrane glycoprotein NMB(GPNMB) ELISA kit (CSB-EL009727HU)
驗證數(shù)據(jù)
貨號：CSB-EL009727HU
規(guī)格：96T/48T
靈敏度：0.195 ng/mL
檢測范圍：0.78 ng/mL-50 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
GPNMB Antibodies
GPNMB for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA009727GA01HU | GPNMB Antibody | Human,Mouse | ELISA,IHC |
| CSB-RA622928MA1HU | GPNMB Recombinant Monoclonal Antibody | Human | ELISA, FC |
GPNMB Proteins
GPNMB Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP622928HU CSB-EP622928HU CSB-BP622928HU CSB-MP622928HU CSB-EP622928HU-B |
Recombinant Human Transmembrane glycoprotein NMB (GPNMB), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GPNMB Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP740736RA CSB-EP740736RA CSB-BP740736RA CSB-MP740736RA CSB-EP740736RA-B |
Recombinant Rat Transmembrane glycoprotein NMB (Gpnmb), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GPNMB Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP860839MO CSB-EP860839MO CSB-BP860839MO CSB-MP860839MO CSB-EP860839MO-B |
Recombinant Mouse Transmembrane glycoprotein NMB (Gpnmb), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GPNMB ELISA Kit
GPNMB ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL009727HU | Human Transmembrane glycoprotein NMB(GPNMB) ELISA kit | serum, plasma, tissue homogenates | 0.195 ng/mL |
| CSB-EL009727HU-IS | Human Transmembrane glycoprotein NMB(GPNMB) ELISA kit | serum, plasma, tissue homogenates, cell culture supernates | 0.039 ng/mL |
GPNMB ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL009727MO | Mouse Transmembrane glycoprotein NMB(GPNMB) ELISA kit | serum, plasma, tissue homogenates | 0.195ng/ml |
