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GPBAR1

GPBAR1,即G蛋白偶聯(lián)膽汁酸受體1,別名TGR5、GPCR19、hGPCR19、M-BAR、BG37等。它來(lái)源于人體細(xì)胞內(nèi)的基因表達(dá),是G蛋白偶聯(lián)受體家族的一員。GPBAR1的作用機(jī)制主要通過(guò)識(shí)別并結(jié)合膽汁酸,激活下游信號(hào)通路,從而參與代謝調(diào)控、炎癥反應(yīng)和能量平衡等生理過(guò)程。在生物學(xué)意義上,GPBAR1對(duì)于維持機(jī)體內(nèi)環(huán)境穩(wěn)定、預(yù)防代謝性疾病和炎癥性疾病具有重要意義,同時(shí)也是藥物研發(fā)的重要靶點(diǎn)之一。

熱銷產(chǎn)品

Recombinant Human?G-protein?coupled?bile?acid?receptor?1 (GPBAR1) (CSB-CF819471HU)

驗(yàn)證數(shù)據(jù)

CSB-CF819471HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

GPBAR1 Antibody (CSB-PA819471LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA819471LA01HU

Western Blot
Positive WB detected in: Mouse kidney tissue
All lanes: GPBAR1 antibody at 6μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 36 kDa
Observed band size: 36 kDa

CSB-PA819471LA01HU

IHC image of CSB-PA819471LA01HU diluted at 1:300 and staining in paraffin-embedded human bladder cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA819471LA01HU

Immunofluorescence staining of 293 cells with CSB-PA819471LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Human G protein-coupled bile acid receptor 1(GPBAR1) ELISA Kit (CSB-E13937h)

驗(yàn)證數(shù)據(jù)

CSB-E13937h 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-E13937h

規(guī)格:96T/48T

靈敏度:0.039 ng/mL

檢測(cè)范圍:0.156 ng/mL-10 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

GPBAR1 Antibodies

GPBAR1 for Homo sapiens (Human)

GPBAR1 Proteins

GPBAR1 Proteins for Rattus norvegicus (Rat)

GPBAR1 Proteins for Oryctolagus cuniculus (Rabbit)

GPBAR1 Proteins for Bos taurus (Bovine)

GPBAR1 Proteins for Mus musculus (Mouse)

GPBAR1 Proteins for Homo sapiens (Human)

GPBAR1 ELISA Kit

GPBAR1 ELISA Kit for Homo sapiens (Human)