GFRA1
GFRα1（膠質(zhì)細(xì)胞源性神經(jīng)營養(yǎng)因子受體α1）是GDNF家族配體的核心受體之一，通過與RET酪氨酸激酶受體形成復(fù)合物調(diào)控神經(jīng)元存活與分化。該蛋白在胚胎發(fā)育期對(duì)交感神經(jīng)、腎臟及腸道神經(jīng)系統(tǒng)的形成起關(guān)鍵作用，其功能異常可能引發(fā)先天性巨結(jié)腸癥、多巴胺能神經(jīng)元退化等疾病。近年研究發(fā)現(xiàn)GFRα1在甲狀腺癌、神經(jīng)母細(xì)胞瘤中存在異常表達(dá)，其介導(dǎo)的RET信號(hào)過度激活與腫瘤侵襲轉(zhuǎn)移密切相關(guān)。針對(duì)這一通路開發(fā)的凡德他尼、卡博替尼等RET抑制劑已獲批用于甲狀腺髓樣癌治療，而基于GDNF-GFRα1系統(tǒng)的基因療法在帕金森病動(dòng)物模型中展現(xiàn)出神經(jīng)保護(hù)潛力。目前重組GDNF蛋白的鞘內(nèi)給藥方案正在進(jìn)行Ⅱ期臨床試驗(yàn)，旨在為肌萎縮側(cè)索硬化等神經(jīng)退行性疾病提供新治療策略。
熱銷產(chǎn)品
GFRA1 Antibody (CSB-PA009379LA01HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: MCF-7 whole cell lysate, Mouse kidney tissue
All lanes: GFRA1 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 52, 51 kDa
Observed band size: 52 kDa
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA009379LA01HU at dilution of 1:100
Immunofluorescent analysis of A549 cells using CSB-PA009379LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
GFRA1 Antibodies
GFRA1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA008804 | GFRA1 Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA449746 | GFRA1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA009379LA01HU | GFRA1 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA009379LB01HU | GFRA1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA009379LC01HU | GFRA1 Antibody, FITC conjugated | Human | |
| CSB-PA009379LD01HU | GFRA1 Antibody, Biotin conjugated | Human | ELISA |
GFRA1 Proteins
GFRA1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP009379HU CSB-EP009379HU CSB-BP009379HU CSB-MP009379HU CSB-EP009379HU-B |
Recombinant Human GDNF family receptor alpha-1 (GFRA1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
