GDF2
GDF2，即生長(zhǎng)分化因子2，別名BMP-9、BMP9，屬于轉(zhuǎn)化生長(zhǎng)因子β超家族（TGF-beta superfamily）中的BMP亞群成員。GDF2主要通過與ALK1等受體結(jié)合，傳遞信號(hào)，從而調(diào)節(jié)多種胚胎和成體組織的發(fā)育和功能。GDF2的作用機(jī)制涉及與ALK1等受體的結(jié)合，激活下游的Smad蛋白，進(jìn)而影響基因表達(dá)。GDF2在肝臟非實(shí)質(zhì)細(xì)胞中合成分泌，能夠促進(jìn)脂質(zhì)代謝并抑制葡萄糖生成。它在胚胎中樞神經(jīng)系統(tǒng)中對(duì)膽堿能神經(jīng)元表型的發(fā)育和維持起著重要作用，同時(shí)也誘導(dǎo)間充質(zhì)干細(xì)胞分化為軟骨細(xì)胞系。GDF2的功能還包括調(diào)節(jié)血管生成、影響內(nèi)皮細(xì)胞增殖以及參與骨骼和軟骨的發(fā)育。GDF2的異常表達(dá)與遺傳性出血性毛細(xì)血管擴(kuò)張癥相關(guān)。
熱銷產(chǎn)品
Recombinant Human Growth/differentiation factor 2 (GDF2) (CSB-EP892325HU1)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
GDF2 Antibody (CSB-PA892325LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA892325LA01HU at dilution of 1:100
GDF2 Antibodies
GDF2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA892325GA01HU | GDF2 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA886231 | GDF2 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA356766 | GDF2 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA892325LA01HU | GDF2 Antibody | Human | ELISA, IHC |
| CSB-PA892325LD01HU | GDF2 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA892325LC01HU | GDF2 Antibody, FITC conjugated | Human | |
| CSB-PA892325LB01HU | GDF2 Antibody, HRP conjugated | Human | ELISA |
GDF2 Proteins
GDF2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP892325HU1 | Recombinant Human Growth/differentiation factor 2 (GDF2), partial | Yeast |
| CSB-EP892325HU1 | Recombinant Human Growth/differentiation factor 2 (GDF2) | E.coli |
GDF2 ELISA Kit
GDF2 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E11769h | Human growth differentiation factor 2,GDF2 ELISA Kit | serum, plasma,tissue homogenates | 0.98 pg/mL |
