FOSL1
FOSL1（FOS-like antigen 1）又稱Fra-1，屬于AP-1轉(zhuǎn)錄因子家族成員，在細(xì)胞增殖、分化和凋亡中發(fā)揮調(diào)控作用。FOSL1通過與JUN家族蛋白形成二聚體，結(jié)合特定DNA序列激活下游靶基因，尤其與腫瘤侵襲轉(zhuǎn)移密切相關(guān)。有研究發(fā)現(xiàn)，F(xiàn)OSL1在乳腺癌、結(jié)直腸癌和肺癌等多種惡性腫瘤中異常高表達(dá)，通過誘導(dǎo)上皮間質(zhì)轉(zhuǎn)化（EMT）促進(jìn)癌細(xì)胞遷移，并與血管生成、化療耐藥等惡性表型相關(guān)。其活性受MAPK/ERK和JNK等信號(hào)通路調(diào)控，與炎癥因子TNF-α、IL-6的表達(dá)也存在交叉調(diào)控。目前針對(duì)FOSL1尚無(wú)直接靶向藥物，但針對(duì)其上游信號(hào)分子開發(fā)的MEK抑制劑（如曲美替尼）已在臨床試驗(yàn)中驗(yàn)證對(duì)部分腫瘤的療效。近年研究發(fā)現(xiàn)，天然化合物姜黃素可通過抑制FOSL1表達(dá)延緩腫瘤進(jìn)展，為聯(lián)合用藥提供了新方向。
熱銷產(chǎn)品
FOSL1 Antibody (CSB-PA008792DSR1HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA008792DSR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA008792DSR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA008792DSR1HU at dilution of 1:100
FOSL1 Antibodies
FOSL1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA679637 | FOSL1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA008792DSR1HU | FOSL1 Antibody | Human | ELISA, IHC |
| CSB-PA002578 | FOSL1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA940383 | FOSL1 Antibody | Human,Rat | ELISA,WB |
| CSB-PA569524 | FOSL1 Antibody | Human,Rat | ELISA,WB,IHC |
FOSL1 Proteins
FOSL1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP008792RA CSB-EP008792RA CSB-BP008792RA CSB-MP008792RA CSB-EP008792RA-B |
Recombinant Rat Fos-related antigen 1 (Fosl1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FOSL1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-BP008792HU CSB-MP008792HU CSB-EP008792HU-B |
Recombinant Human Fos-related antigen 1 (FOSL1) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FOSL1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP008792MO CSB-BP008792MO CSB-MP008792MO CSB-EP008792MO-B |
Recombinant Mouse Fos-related antigen 1 (Fosl1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
