FGG

纖維蛋白原γ鏈（Fibrinogen Gamma Chain，F(xiàn)GG）是纖維蛋白原復(fù)合物的核心組分，與α、β鏈共同構(gòu)成血漿中重要的凝血蛋白，在UniProt中記錄為FGgamma或Fibrinogen gamma polypeptide。該蛋白在凝血級聯(lián)反應(yīng)中發(fā)揮關(guān)鍵作用，凝血酶將其切割后釋放纖維蛋白單體，通過交聯(lián)形成網(wǎng)狀結(jié)構(gòu)，穩(wěn)定血栓并促進(jìn)傷口愈合。其異常表達(dá)或功能缺陷可能引發(fā)先天性纖維蛋白原缺乏癥，表現(xiàn)為出血傾向或異常血栓形成，部分突變還與遺傳性淀粉樣變性相關(guān)。臨床研究發(fā)現(xiàn)，血漿FGG水平升高與動脈粥樣硬化、深靜脈血栓及腫瘤轉(zhuǎn)移風(fēng)險(xiǎn)顯著相關(guān)，尤其在肝癌、胰腺癌中常作為預(yù)后標(biāo)志物。目前針對纖維蛋白原的藥物以抗凝劑為主，如直接凝血酶抑制劑比伐盧定，而針對FGG特異性的單克隆抗體尚處于臨床前研究階段。近年來，基于FGG結(jié)構(gòu)設(shè)計(jì)的靶向纖維蛋白溶解療法在溶栓藥物開發(fā)中受到關(guān)注，例如改良型組織纖溶酶原激活劑（tPA）的增效策略已進(jìn)入Ⅱ期臨床試驗(yàn)。

熱銷產(chǎn)品

Recombinant Human Fibrinogen gamma chain (FGG) (CSB-EP008651HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

FGG Antibody (CSB-PA008651LA01HU)

驗(yàn)證數(shù)據(jù)

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA008651LA01HU at dilution of 1:100

Immunofluorescent analysis of Hela cells using CSB-PA008651LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Western Blot
Positive WB detected in: Mouse heart tissue
All lanes: FGG antibody at 2.7μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 52, 50 kDa
Observed band size: 52 kDa

Human Fibrinogen Gamma Chain (FGG)ELISA Kit (CSB-E13319h)

驗(yàn)證數(shù)據(jù)

貨號：CSB-E13319h

規(guī)格：96T/48T

靈敏度：31.25 ng/mL

檢測范圍：125 ng/mL-8000 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

FGG Antibody

FGG Protein

FGG ELISA Kit

FGG Antibodies

FGG for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA008651GA01HU	FGG Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA008651LA01HU	FGG Antibody	Human, Mouse	ELISA, WB, IHC, IF
CSB-PA008651LB01HU	FGG Antibody, HRP conjugated	Human	ELISA
CSB-PA008651LC01HU	FGG Antibody, FITC conjugated	Human
CSB-PA008651LD01HU	FGG Antibody, Biotin conjugated	Human	ELISA

FGG Proteins

FGG Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP008651DO CSB-EP008651DO CSB-BP008651DO CSB-MP008651DO CSB-EP008651DO-B	Recombinant Dog Fibrinogen gamma chain (FGG)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FGG Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP008651RA CSB-EP008651RA CSB-BP008651RA CSB-MP008651RA CSB-EP008651RA-B	Recombinant Rat Fibrinogen gamma chain (Fgg)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FGG Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP008651HU CSB-BP008651HU CSB-MP008651HU CSB-EP008651HU-B	Recombinant Human Fibrinogen gamma chain (FGG)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP008651HU	Recombinant Human Fibrinogen gamma chain (FGG)	E.coli

FGG Proteins for Xenopus laevis (African clawed frog)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP008651XBE CSB-EP008651XBE CSB-BP008651XBE CSB-MP008651XBE CSB-EP008651XBE-B	Recombinant Xenopus laevis Fibrinogen gamma chain (fgg)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FGG Proteins for Petromyzon marinus (Sea lamprey)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP008651EUC CSB-EP008651EUC CSB-BP008651EUC CSB-MP008651EUC CSB-EP008651EUC-B	Recombinant Petromyzon marinus Fibrinogen gamma chain (FGG)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FGG Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP008651MO CSB-EP008651MO CSB-BP008651MO CSB-MP008651MO CSB-EP008651MO-B	Recombinant Mouse Fibrinogen gamma chain (Fgg)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli