FCGR2A
FCGR2A蛋白全稱為免疫球蛋白G Fc段受體IIa，又稱CD32a，是白細(xì)胞表面一類關(guān)鍵受體，負(fù)責(zé)識(shí)別抗體標(biāo)記的病原體或異常細(xì)胞。該蛋白主要分布于巨噬細(xì)胞、中性粒細(xì)胞等免疫細(xì)胞，通過(guò)結(jié)合IgG抗體的Fc段觸發(fā)吞噬清除或炎癥介質(zhì)釋放，在抗感染和自身免疫平衡中扮演雙重角色。其遺傳多態(tài)性與系統(tǒng)性紅斑狼瘡、類風(fēng)濕關(guān)節(jié)炎等自身免疫疾病易感性顯著相關(guān)，某些變異體還影響患者對(duì)肺炎鏈球菌等病原體的清除能力。
近年來(lái)針對(duì)FCGR2A的治療策略呈現(xiàn)兩極分化：?jiǎn)慰顾幬锶缣胬桌閱慰雇ㄟ^(guò)增強(qiáng)受體激活強(qiáng)化腫瘤免疫應(yīng)答，而Fc工程化改造的抗體片段（如VIB9600）則選擇性抑制受體功能以緩解自身免疫反應(yīng)。2023年進(jìn)入Ⅱ期臨床試驗(yàn)的拮抗劑CPI-006顯示出調(diào)控新冠重癥患者細(xì)胞因子風(fēng)暴的潛力。該受體還被用于設(shè)計(jì)雙特異性抗體支架，旨在提高CAR-T細(xì)胞對(duì)實(shí)體瘤的識(shí)別效率，相關(guān)研究尚處于臨床前階段。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human FCGR2A at 2 μg/ml can bind Anti-FCGR2A recombinant antibody (CSB-RA008540MA1HU). The EC50 is 24.44-32.57 ng/mL.
The purity of FCGR2A was greater than 90% as determined by SEC-HPLC
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
FCGR2A Recombinant Monoclonal Antibody (CSB-RA163349A0HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: THP-1 whole cell lysate
All lanes: CD32 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 35, 36 kDa
Observed band size: 45 kDa
FCGR2A Antibodies
FCGR2A for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA008540GA01HU | FCGR2A Antibody | Human | ELISA,WB |
| CSB-PA985077 | FCGR2A Antibody | Human | ELISA,WB |
| CSB-PA005203 | FCGR2A Antibody | Human | WB, ELISA |
| CSB-PA04459A0Rb | FCGR2A Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA04459B0Rb | FCGR2A Antibody, HRP conjugated | Human | ELISA |
| CSB-PA04459C0Rb | FCGR2A Antibody, FITC conjugated | Human | |
| CSB-PA04459D0Rb | FCGR2A Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA163349A0HU | FCGR2A Recombinant Monoclonal Antibody | Human | ELISA, WB |
FCGR2A Proteins
FCGR2A Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-BP008540HU1 CSB-EP008540HU1-B |
Recombinant Human Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A), partial | Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF008540HU | Recombinant Human Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A) | in vitro E.coli expression system |
| CSB-MP008540HU1 | Recombinant Human Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A), partial (Active) | Mammalian cell |
| CSB-EP008540HU1 | Recombinant Human Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A), partial | E.coli |
| CSB-YP008540HU1 | Recombinant Human Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A), partial | Yeast |
FCGR2A Proteins for Pan troglodytes (Chimpanzee)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP823360EQV CSB-EP823360EQV CSB-BP823360EQV CSB-MP823360EQV CSB-EP823360EQV-B |
Recombinant Pan troglodytes Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
