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FCAR

FCAR(FcαRI),全稱為高親和力免疫球蛋白E受體I,常見別名包括CD89。該蛋白主要表達于嗜酸性粒細胞、肥大細胞和血小板等細胞上,其核心功能是介導免疫球蛋白E(IgE)與靶細胞結合,引發I型超敏反應及其他免疫應答。FCAR通過與IgE結合,激活下游信號分子,如磷脂酰肌醇3-激酶(PI3K)和蛋白激酶C(PKC),進而促進細胞脫顆粒、釋放炎癥介質和趨化因子,參與過敏反應和抗感染過程。此外,FCAR還與某些自身免疫性疾病和腫瘤的發病機制相關,例如過敏性哮喘、過敏性鼻炎和某些血液系統腫瘤。在藥物研發領域,針對FCAR的抑制劑被開發用于治療過敏性疾病,如抗IgE抗體和FCAR單克隆抗體,以減少IgE介導的過度炎癥反應。目前,相關藥物已進入臨床試驗階段,顯示出良好的治療效果和安全性。

熱銷產品

FCAR Antibody (CSB-PA258899)

驗證數據

CSB-PA258899

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA258899(FCAR Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)

CSB-PA258899

The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA258899(FCAR Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)

CSB-PA258899

Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: CSB-PA258899(FCAR Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds

FCAR Antibodies

FCAR for Homo sapiens (Human)

FCAR Proteins

FCAR Proteins for Homo sapiens (Human)