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FADS1

FADS1,全稱為脂肪酸去飽和酶1,常被稱為Δ-5去飽和酶。它在人體脂肪酸代謝中發揮關鍵作用,能將亞油酸等普通不飽和脂肪酸轉化為花生四烯酸這類身體必需的活性成分——這些成分不僅構成細胞膜的重要部分,影響細胞彈性與物質交換,還參與炎癥反應、激素合成等生理過程的調控。
FADS1活性異常,可能打破體內脂肪酸平衡,與高血脂、2型糖尿病、動脈粥樣硬化等代謝及心血管問題相關,部分炎癥性疾病如類風濕關節炎的發生也可能與其功能失調有關。目前科研人員正探索調節其活性的物質,希望借此改善代謝紊亂或炎癥狀態,這類研究多處于實驗室或早期臨床試驗階段。

熱銷產品

FADS1 Recombinant Monoclonal Antibody (CSB-RA155442A0HU)

驗證數據

CSB-RA155442A0HU

Western Blot
Positive WB detected in: MCF-7 whole cell lysate, A549 whole cell lysate, Hela whole cell lysate
All lanes: FADS1 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 52, 43 kDa
Observed band size: 55 kDa

CSB-RA155442A0HU

IHC image of CSB-RA155442A0HU diluted at 1:100 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA155442A0HU

Immunofluorescence staining of HepG2 cell with CSB-RA155442A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 565-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-RA155442A0HU

Overlay Peak curve showing HepG2 cells stained with CSB-RA155442A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

FADS1 Antibody (CSB-PA007959LA01HU)

驗證數據

CSB-PA007959LA01HU

Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA007959LA01HU at dilution of 1:100

CSB-PA007959LA01HU

Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA007959LA01HU at dilution of 1:100

CSB-PA007959LA01HU

Immunofluorescent analysis of HepG2 cells using CSB-PA007959LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

CSB-PA007959LA01HU

Western Blot
Positive WB detected in: Hela whole cell lysate, SH-SY5Y whole cell lysate
All lanes: FADS1 antibody at 3.4µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 52, 43 kDa
Observed band size: 52 kDa

FADS1 Antibodies

FADS1 for Homo sapiens (Human)

FADS1 Proteins

FADS1 Proteins for Homo sapiens (Human)