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EYA4

Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity).

EYA4 Antibodies

EYA4 for Homo sapiens (Human)

EYA4 Proteins

EYA4 Proteins for Homo sapiens (Human)

EYA4 Proteins for Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)



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