EFNA1

EFNA1，全稱Ephrin-A1，也被稱為EPLG1、LERK1、TNFAIP4或B61，屬于Ephrin家族。該蛋白是一種細(xì)胞表面GPI結(jié)合配體，能與Eph受體相互作用，Eph受體是受體酪氨酸激酶家族成員，對(duì)神經(jīng)元、血管和上皮發(fā)育過(guò)程中的遷移、排斥和粘附至關(guān)重要。EFNA1通過(guò)混雜結(jié)合相鄰細(xì)胞上的Eph受體，引發(fā)接觸依賴的雙向信號(hào)傳導(dǎo)，參與血管生成和腫瘤新生血管形成。研究發(fā)現(xiàn)，EFNA1過(guò)表達(dá)與多種癌癥轉(zhuǎn)移相關(guān)，抑制其表達(dá)可減少腫瘤血管化，因此EFNA1/EphA2軸成為抗癌藥物開(kāi)發(fā)的潛在靶點(diǎn)。目前，針對(duì)EFNA1的藥物研發(fā)主要集中在靶向其與Eph受體結(jié)合的抑制劑，以及通過(guò)調(diào)節(jié)EFNA1表達(dá)來(lái)干預(yù)腫瘤轉(zhuǎn)移和血管生成等病理過(guò)程。

熱銷產(chǎn)品

Recombinant Human Ephrin-A1 (EFNA1) (Active) (CSB-MP007460HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human EPHA2 (CSB-MP007722HUd7) at 2 μg/ml can bind Human EFNA1. The EC₅₀ is 5.859-7.758 ng/mL.

EFNA1 Antibody (CSB-PA007460ESR1HU)

驗(yàn)證數(shù)據(jù)

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA007460ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA007460ESR1HU at dilution of 1:100

Human Ephrin-A1(EFNA1) ELISA kit (CSB-EL007460HU)

驗(yàn)證數(shù)據(jù)

貨號(hào)：CSB-EL007460HU

規(guī)格：96T/48T

靈敏度：0.039 ng/mL

檢測(cè)范圍：0.156 ng/mL-10 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

EFNA1 Antibody

EFNA1 Protein

EFNA1 ELISA Kit

EFNA1 Antibodies

EFNA1 for Rattus norvegicus (Rat)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA007460LA01RA	Efna1 Antibody	Rat	ELISA

EFNA1 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA007460ESR1HU	EFNA1 Antibody	Human	ELISA, IHC
CSB-PA551061	EFNA1 Antibody	Human,Mouse,Rat	ELISA,WB,IF
CSB-PA002367	EFNA1 Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA256498	EFNA1 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA999540	EFNA1 Antibody	Human,Mouse,Rat	ELISA,IHC

EFNA1 Proteins

EFNA1 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP007460RA	Recombinant Rat Ephrin-A1 (Efna1)	Yeast
CSB-EP007460RAe0	Recombinant Rat Ephrin-A1 (Efna1)	E.coli
CSB-EP007460RA	Recombinant Rat Ephrin-A1 (Efna1)	E.coli
CSB-BP007460RA CSB-MP007460RA CSB-EP007460RA-B	Recombinant Rat Ephrin-A1 (Efna1)	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

EFNA1 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP007460HU CSB-BP007460HU CSB-EP007460HU-B	Recombinant Human Ephrin-A1 (EFNA1)	Yeast Baculovirus In Vivo Biotinylation in E.coli
CSB-EP007460HU	Recombinant Human Ephrin-A1 (EFNA1)	E.coli
CSB-AP005711HU	Recombinant Human Ephrin-A1 (EFNA1) (Active)	Mammalian cell
CSB-MP007460HU	Recombinant Human Ephrin-A1 (EFNA1) (Active)	Mammalian cell

EFNA1 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP007460MO CSB-EP007460MO CSB-BP007460MO CSB-MP007460MO CSB-EP007460MO-B	Recombinant Mouse Ephrin-A1 (Efna1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-AP005771MO	Recombinant Mouse Ephrin-A1 (Efna1), partial (Active)	Mammalian cell

EFNA1 Proteins for Xenopus laevis (African clawed frog)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP007460XBE CSB-EP007460XBE CSB-BP007460XBE CSB-MP007460XBE CSB-EP007460XBE-B	Recombinant Xenopus laevis Ephrin-A1 (efna1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

EFNA1 Proteins for Bos taurus (Bovine)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP007460BO CSB-EP007460BO CSB-BP007460BO CSB-MP007460BO CSB-EP007460BO-B	Recombinant Bovine Ephrin-A1 (EFNA1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli