EDNRA
內(nèi)皮素受體A型（Endothelin Receptor Type A，簡(jiǎn)稱EDNRA）是一種G蛋白偶聯(lián)受體，也被稱為ET-A或ETAR，主要分布于血管平滑肌細(xì)胞。EDNRA選擇性結(jié)合內(nèi)皮素-1（ET-1）后，通過(guò)激活磷脂酶C和鈣離子信號(hào)引發(fā)血管強(qiáng)烈收縮，同時(shí)促進(jìn)細(xì)胞增殖與纖維化，其異常激活與肺動(dòng)脈高壓、雷諾氏綜合征密切相關(guān)。在腫瘤微環(huán)境中，EDNRA的高表達(dá)與前列腺癌、卵巢癌的侵襲轉(zhuǎn)移相關(guān)，可能通過(guò)調(diào)控血管新生和基質(zhì)重塑促進(jìn)腫瘤進(jìn)展。
目前全球已上市選擇性EDNRA拮抗劑包括安貝生坦（治療肺動(dòng)脈高壓）和西他生坦，但后者因肝毒性退市。2023年進(jìn)入III期臨床的Zibotentan聯(lián)合療法在糖尿病腎病領(lǐng)域展現(xiàn)潛力。研究發(fā)現(xiàn)EDNRA抑制劑聯(lián)合免疫檢查點(diǎn)藥物可改善腫瘤治療效果，但需警惕體位性低血壓等副作用。該靶點(diǎn)的新劑型開發(fā)與聯(lián)合用藥策略成為近年研究熱點(diǎn)。
熱銷產(chǎn)品
Recombinant Human Endothelin-1 receptor (EDNRA)-VLPs (Active) (CSB-MP007403HU)
驗(yàn)證數(shù)據(jù)
CSB-MP007403HU is detected by Mouse anti-6*His monoclonal antibody.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human EDNRA at 10 μg/ml can bind Anti-EDNRA recombinant antibody(CSB-RA007403MA3HU). The EC50 is 2.225-3.570 ng/mL.The VLPs (CSB-MP3838) is negative control.
The purity of VLPs was greater than 95% as determined by SEC-HPLC
EDNRA (Getagozumab) Recombinant Monoclonal Antibody (CSB-RA007403MA3HU)
驗(yàn)證數(shù)據(jù)
The Binding Activity of Human EDNRA with Anti-EDNRA Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human EDNRA(CSB-MP007403HU) at 10 μg/mL can bind Anti-EDNRA recombinant antibody. The EC50 is 2.225-3.570 ng/mL.
The VLPs (CSB-MP3838) is negative control.
EDNRA Antibodies
EDNRA for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA002447 | EDNRA Antibody | Human,Mouse,Monkey | WB, IHC, IF, ELISA |
| CSB-PA002449 | EDNRA Antibody | Human,Mouse,Rat | WB, IF, ELISA |
| CSB-PA299262 | EDNRA Antibody | Human,Mouse | ELISA,WB,IHC |
EDNRA Proteins
EDNRA Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP007403BO1 CSB-EP007403BO1 CSB-BP007403BO1 CSB-MP007403BO1 CSB-EP007403BO1-B |
Recombinant Bovine Endothelin-1 receptor (EDNRA), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF007403BO | Recombinant Bovine Endothelin-1 receptor (EDNRA) | in vitro E.coli expression system |
EDNRA Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP007403RA1 CSB-EP007403RA1 CSB-BP007403RA1 CSB-MP007403RA1 CSB-EP007403RA1-B |
Recombinant Rat Endothelin-1 receptor (Ednra), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF007403RA | Recombinant Rat Endothelin-1 receptor (Ednra) | in vitro E.coli expression system |
EDNRA Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP644898PI1 CSB-EP644898PI1 CSB-BP644898PI1 CSB-MP644898PI1 CSB-EP644898PI1-B |
Recombinant Pig Endothelin-1 receptor (EDNRA), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF644898PI | Recombinant Pig Endothelin-1 receptor (EDNRA) | in vitro E.coli expression system |
EDNRA Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP692301DO1 CSB-EP692301DO1 CSB-BP692301DO1 CSB-MP692301DO1 CSB-EP692301DO1-B |
Recombinant Dog Endothelin-1 receptor (EDNRA), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF692301DO | Recombinant Dog Endothelin-1 receptor (EDNRA) | in vitro E.coli expression system |
EDNRA Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP737038MO1 CSB-EP737038MO1 CSB-BP737038MO1 CSB-MP737038MO1 CSB-EP737038MO1-B |
Recombinant Mouse Endothelin-1 receptor (Ednra), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF737038MO | Recombinant Mouse Endothelin-1 receptor (Ednra) | in vitro E.coli expression system |
EDNRA Proteins for Ovis aries (Sheep)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP839205SH1 CSB-EP839205SH1 CSB-BP839205SH1 CSB-MP839205SH1 CSB-EP839205SH1-B |
Recombinant Sheep Endothelin-1 receptor (EDNRA), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF839205SH | Recombinant Sheep Endothelin-1 receptor (EDNRA) | in vitro E.coli expression system |
EDNRA Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP007403HU1 | Recombinant Human Endothelin-1 receptor (EDNRA), partial | Yeast |
| CSB-CF007403HU | Recombinant Human Endothelin-1 receptor (EDNRA) | in vitro E.coli expression system |
| CSB-EP007403HU1 CSB-BP007403HU1 CSB-MP007403HU1 CSB-EP007403HU1-B |
Recombinant Human Endothelin-1 receptor (EDNRA), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-MP007403HU | Recombinant Human Endothelin-1 receptor (EDNRA)-VLPs (Active) | Mammalian cell |
