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DNMT3B

DNMT3B,即DNA甲基轉移酶3β,別名ICF、ICF1。DNMT3B是一種DNA甲基轉移酶,主要在胚胎發育早期表達和活躍,負責從頭甲基化,即在DNA序列中添加甲基基團到胞嘧啶的第五碳原子上。DNMT3B將甲基從S-腺苷甲硫氨酸(SAM)轉移到胞嘧啶上,這一過程對基因表達調控、胚胎發育、細胞分化、基因印記、轉座子沉默和X染色體失活等生理過程至關重要。DNMT3B在維持DNA甲基化模式、基因表達調控和染色質結構中發揮重要作用。DNMT3B的異常表達或功能失調與多種疾病相關,包括免疫缺陷、中心粒不穩定和面部異常綜合征(ICF綜合征)以及腫瘤的發生發展。

熱銷產品

DNMT3B Antibody (CSB-PA883358HA01HU)

驗證數據

CSB-PA883358HA01HU

Western blot
All lanes: DNMT3B antibody at 14µg/ml + Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 96, 94, 87, 81, 89, 95, 78, 82 kDa
Observed band size: 96, 37 kDa

CSB-PA883358HA01HU

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA883358HA01HU at dilution of 1:100

CSB-PA883358HA01HU

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA883358HA01HU at dilution of 1:100

CSB-PA883358HA01HU

Immunofluorescent analysis of HepG2 cells using CSB-PA883358HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

DNMT3B Antibodies

DNMT3B for Homo sapiens (Human)

DNMT3B Proteins

DNMT3B Proteins for Homo sapiens (Human)