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DNMT1

DNMT1,即DNA甲基轉(zhuǎn)移酶1,別名AIM、DNMT、MCMT、CXXC9、HSN1E、ADCADN、m.HsaI等。DNMT1由人類DNMT1基因編碼,該基因位于19號染色體上。DNMT1是一種酶,負責(zé)在DNA復(fù)制過程中將甲基基團轉(zhuǎn)移至新合成的DNA鏈上,以維持DNA甲基化模式的穩(wěn)定性和遺傳信息的傳遞。其作用機制主要是通過識別半甲基化的DNA并催化甲基化反應(yīng),對維持基因表達模式和基因沉默至關(guān)重要。DNMT1在調(diào)控基因表達、胚胎發(fā)育、細胞分化以及腫瘤發(fā)生中扮演重要角色。異常的DNA甲基化模式與多種疾病相關(guān),包括癌癥和發(fā)育異常。

熱銷產(chǎn)品

DNMT1 Recombinant Monoclonal Antibody (CSB-RA160202A0HU)

驗證數(shù)據(jù)

CSB-RA160202A0HU

IHC image of CSB-RA160202A0HU diluted at 1:100 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA160202A0HU

Immunofluorescence staining of HepG2 Cells with CSB-RA160202A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

DNMT1 Antibodies

DNMT1 for Homo sapiens (Human)

DNMT1 Proteins

DNMT1 Proteins for Mus musculus (Mouse)

DNMT1 Proteins for Homo sapiens (Human)

DNMT1 Proteins for Bos taurus (Bovine)

DNMT1 Proteins for Gallus gallus (Chicken)



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