DLK1

DLK1，全稱為delta like non-canonical Notch ligand 1，是一種表皮生長(zhǎng)因子樣同源異型家族成員，屬于跨膜蛋白。該蛋白在多種組織中低表達(dá)，但在胎盤(pán)、垂體等少數(shù)組織中高表達(dá)。DLK1蛋白由N端的信號(hào)肽、6個(gè)表皮生長(zhǎng)因子結(jié)構(gòu)域、一個(gè)跨膜結(jié)構(gòu)域及C端的胞內(nèi)肽段組成。DLK1蛋白可與Notch/Delta/Serrate蛋白家族成員相互作用，但在激活下游信號(hào)通路方面與經(jīng)典配體DLL1不同。DLK1蛋白參與多種細(xì)胞分化過(guò)程的調(diào)節(jié)，包括神經(jīng)內(nèi)分泌分化、脂肪細(xì)胞分化和間充質(zhì)干細(xì)胞分化等。DLK1蛋白在神經(jīng)母細(xì)胞瘤、肝癌、腎癌等多種腫瘤組織中異常高表達(dá)，與腫瘤的發(fā)生發(fā)展密切相關(guān)。研究表明，DLK1蛋白可通過(guò)上調(diào)細(xì)胞周期蛋白CyclinB1的表達(dá)水平，促進(jìn)腫瘤細(xì)胞的增殖。此外，DLK1蛋白還參與抑制造血過(guò)程，其表達(dá)水平與兒童和青少年肥胖相關(guān)。目前，針對(duì)DLK1蛋白的藥物研發(fā)尚處于早期階段，但已有研究證實(shí)，通過(guò)抑制DLK1蛋白的表達(dá)或活性，可以有效抑制腫瘤細(xì)胞的增殖和轉(zhuǎn)移，為腫瘤治療提供新的思路。

熱銷產(chǎn)品

Recombinant Human Protein delta homolog 1 (DLK1), partial (Active) (CSB-MP006945HUd7)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human DLK1 at 2 μg/ml can bind Anti-DLK1 recombinant antibody (CSB-RA006945MA1HU). The EC₅₀ is 1.598-1.804 ng/mL.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human DLK1 at 2 μg/ml can bind Anti-DLK1 recombinant antibody (CSB-RA006945MA2HU). The EC₅₀ is 1.935-2.143 ng/mL.

The purity of DLK1 was greater than 95% as determined by SEC-HPLC

Recombinant Human Protein delta homolog 1 (DLK1), partial (CSB-EP006945HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

DLK1 Recombinant Monoclonal Antibody (CSB-RA006945MA1HU)

驗(yàn)證數(shù)據(jù)

The Binding Activity of Human DLK1 with Anti-DLK1 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human DLK1 protein (CSB-MP006945HUd7) at 2 μg/mL can bind Anti-DLK1 recombinant antibody. The EC₅₀ is 1.598-1.804 ng/mL.

DLK1 Antibody

DLK1 Protein

DLK1 ELISA Kit

DLK1 Antibodies

DLK1 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA006945GA01HU	DLK1 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA006945LA01HU	DLK1 Antibody	Human, Rat	ELISA, WB, IHC, IF
CSB-PA824488	DLK1 Antibody	Human	ELISA,WB
CSB-PA120648	DLK1 Antibody	Human,Mouse	ELISA,WB
CSB-RA006945MA1HU	DLK1 Recombinant Monoclonal Antibody	Human	ELISA
CSB-RA006945MA2HU	DLK1 Recombinant Monoclonal Antibody	Human	ELISA

DLK1 Proteins

DLK1 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP006945HU	Recombinant Human Protein delta homolog 1 (DLK1), partial	Yeast
CSB-EP006945HU	Recombinant Human Protein delta homolog 1 (DLK1), partial	E.coli
CSB-MP006945HU	Recombinant Human Protein delta homolog 1 (DLK1), partial	Mammalian cell
CSB-BP006945HU CSB-EP006945HU-B	Recombinant Human Protein delta homolog 1 (DLK1), partial	Baculovirus In Vivo Biotinylation in E.coli
CSB-MP006945HUd7	Recombinant Human Protein delta homolog 1 (DLK1), partial (Active)	Mammalian cell