DHODH
DHODH，全稱為二氫乳清酸脫氫酶，是在線粒體中參與嘧啶核苷酸合成的關鍵酶類，有時也被簡稱為DHOD。它的核心功能是催化嘧啶合成過程中的關鍵步驟，為細胞生成DNA、RNA提供必要的原料，因此與細胞的生長和分裂過程緊密相關。
DHODH活性變化會影響細胞增殖的平衡狀態，進而與多種疾病存在關聯：在肺癌、腸癌等多種腫瘤組織中，其表達水平常顯著升高，助力腫瘤細胞快速分裂；而在類風濕關節炎等自身免疫疾病里，它的過度活躍也可能加劇炎癥反應的持續發展。藥物研發方面，臨床中常用的來氟米特，其體內活性代謝物可通過調控該蛋白功能緩解類風濕關節炎癥狀；此外，多款新型靶向藥物正處于研發階段，嘗試通過精準作用于它阻斷腫瘤細胞原料供應，部分候選藥物在早期臨床試驗中已展現出抑制腫瘤生長的潛力。
熱銷產品
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
DHODH Antibody (CSB-PA006852LA01HU)
驗證數據
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA006852LA01HU at dilution of 1:100
DHODH Antibodies
DHODH for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA006852GA01HU | DHODH Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA007799 | DHODH Antibody | Human | WB, IHC, ELISA |
| CSB-PA006852LA01HU | DHODH Antibody | Human | ELISA, IHC |
| CSB-PA006852LB01HU | DHODH Antibody, HRP conjugated | Human | ELISA |
DHODH Proteins
DHODH Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006852HU CSB-EP006852HU CSB-BP006852HU CSB-MP006852HU CSB-EP006852HU-B |
Recombinant Human Dihydroorotate dehydrogenase (quinone), mitochondrial (DHODH), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP006852HU1 | Recombinant Human Dihydroorotate dehydrogenase (quinone), mitochondrial (DHODH), partial | E.coli |
| CSB-CF006852HU | Recombinant Human Dihydroorotate dehydrogenase (quinone), mitochondrial (DHODH) | in vitro E.coli expression system |
| CSB-EP006852HU1b0 | Recombinant Human Dihydroorotate dehydrogenase (quinone),mitochondrial (DHODH), partial | E.coli |
| CSB-EP006852HU1d7 | Recombinant Human Dihydroorotate dehydrogenase (quinone), mitochondrial (DHODH), partial | E.coli |
