CXCR2

CXCR2全稱為C-X-C趨化因子受體2型，又稱IL-8受體β或CD182，屬于G蛋白偶聯(lián)受體超家族成員。CXCR2通過與IL-8、GROα等趨化因子結(jié)合，介導(dǎo)中性粒細(xì)胞向炎癥部位遷移，在急慢性炎癥反應(yīng)、組織修復(fù)及腫瘤微環(huán)境調(diào)控中發(fā)揮關(guān)鍵作用。CXCR2異?；罨c慢性阻塞性肺病、銀屑病、類風(fēng)濕性關(guān)節(jié)炎等炎癥性疾病密切相關(guān)，其在多種實體瘤中通過招募髓系抑制細(xì)胞促進(jìn)免疫逃逸的特性也備受關(guān)注。
針對CXCR2的藥物開發(fā)聚焦于小分子拮抗劑，如Navarixin（MK-7123）已完成銀屑病二期臨床試驗，AZD5069在慢阻肺治療中顯示出抑制中性粒細(xì)胞浸潤的效果。由于CXCR2拮抗可能影響正常免疫功能，部分藥物因療效不足或毒副作用終止研發(fā)。目前研究轉(zhuǎn)向聯(lián)合用藥策略，如在胰腺癌治療中與免疫檢查點抑制劑聯(lián)用，或開發(fā)雙重CXCR1/CXCR2抑制劑以增強(qiáng)抗炎效果。該靶點的組織特異性調(diào)控機(jī)制仍是轉(zhuǎn)化醫(yī)學(xué)研究的難點。

熱銷產(chǎn)品

Recombinant Human C-X-C chemokine receptor type 2 (CXCR2)-VLPs (Active) (CSB-MP011673HU(A4))

驗證數(shù)據(jù)

CSB-MP011673HU(A4) is detected by Mouse anti-6*His monoclonal antibody.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CXCR2 at 2 μg/ml can bind Anti-CXCR2 recombinant antibody (CSB-RA011673MA1HU). The EC₅₀ is 0.3741-0.4671 ng/mL. The VLPs (CSB-MP3838) is negative control.

Recombinant Human C-X-C chemokine receptor type 2 (CXCR2), partial (CSB-EP011673HU)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CXCR2 Antibody (CSB-PA011673HA01HU)

驗證數(shù)據(jù)

Immunohistochemistry of paraffin-embedded human lymph node tissue using CSB-PA011673HA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA011673HA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA011673HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

CXCR2 Antibody

CXCR2 Protein

CXCR2 Antibodies

CXCR2 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA011673GA01HU	CXCR2 Antibody	Human	ELISA,WB,IF
CSB-PA974167	Phospho-CXCR2 (Ser347) Antibody	Human,Mouse	ELISA,WB
CSB-PA005633	CXCR2 Antibody	Human	WB, ELISA
CSB-PA009566	Phospho-CXCR2 (S347) Antibody	Human,Mouse	WB, IHC, IF, ELISA
CSB-PA009567	CXCR2 Antibody	Human,Mouse	IF, ELISA
CSB-PA730026	CXCR2 Antibody	Human	ELISA,WB
CSB-PA282080	CXCR2 Antibody	Human	ELISA,WB
CSB-PA011673HA01HU	CXCR2 Antibody	Human	ELISA, IHC, IF
CSB-PA011673HB01HU	CXCR2 Antibody, HRP conjugated	Human	ELISA

CXCR2 Proteins

CXCR2 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP011673HU CSB-BP011673HU CSB-MP011673HU CSB-EP011673HU-B	Recombinant Human C-X-C chemokine receptor type 2 (CXCR2), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP011673HU	Recombinant Human C-X-C chemokine receptor type 2 (CXCR2), partial	E.coli
CSB-CF011673HU(A4)	Recombinant Human C-X-C chemokine receptor type 2 (CXCR2)	in vitro E.coli expression system

CXCR2 Proteins for Oryctolagus cuniculus (Rabbit)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP011673RB1 CSB-EP011673RB1 CSB-BP011673RB1 CSB-MP011673RB1 CSB-EP011673RB1-B	Recombinant Rabbit C-X-C chemokine receptor type 2 (CXCR2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF011673RB	Recombinant Rabbit C-X-C chemokine receptor type 2 (CXCR2)	in vitro E.coli expression system

CXCR2 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP011673RA1 CSB-EP011673RA1 CSB-BP011673RA1 CSB-MP011673RA1 CSB-EP011673RA1-B	Recombinant Rat C-X-C chemokine receptor type 2 (Cxcr2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF011673RA	Recombinant Rat C-X-C chemokine receptor type 2 (Cxcr2)	in vitro E.coli expression system

CXCR2 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP011673MO1 CSB-EP011673MO1 CSB-BP011673MO1 CSB-MP011673MO1 CSB-EP011673MO1-B	Recombinant Mouse C-X-C chemokine receptor type 2 (Cxcr2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF011673MO	Recombinant Mouse C-X-C chemokine receptor type 2 (Cxcr2)	in vitro E.coli expression system
CSB-MP011673MO	Recombinant Mouse C-X-C chemokine receptor type 2 (Cxcr2)-VLPs	Mammalian cell

CXCR2 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP011673DO1 CSB-EP011673DO1 CSB-BP011673DO1 CSB-MP011673DO1 CSB-EP011673DO1-B	Recombinant Dog C-X-C chemokine receptor type 2 (CXCR2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF011673DO	Recombinant Dog C-X-C chemokine receptor type 2 (CXCR2)	in vitro E.coli expression system

CXCR2 Proteins for Macaca mulatta (Rhesus macaque)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP630684MOW1 CSB-EP630684MOW1 CSB-BP630684MOW1 CSB-MP630684MOW1 CSB-EP630684MOW1-B	Recombinant Macaca mulatta C-X-C chemokine receptor type 2 (CXCR2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF630684MOW	Recombinant Macaca mulatta C-X-C chemokine receptor type 2 (CXCR2)	in vitro E.coli expression system

CXCR2 Proteins for Pan troglodytes (Chimpanzee)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP631729EQV1 CSB-EP631729EQV1 CSB-BP631729EQV1 CSB-MP631729EQV1 CSB-EP631729EQV1-B	Recombinant Pan troglodytes C-X-C chemokine receptor type 2 (CXCR2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF631729EQV	Recombinant Pan troglodytes C-X-C chemokine receptor type 2 (CXCR2)	in vitro E.coli expression system

CXCR2 Proteins for Bos taurus (Bovine)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP632950BO1 CSB-EP632950BO1 CSB-BP632950BO1 CSB-MP632950BO1 CSB-EP632950BO1-B	Recombinant Bovine C-X-C chemokine receptor type 2 (CXCR2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF632950BO	Recombinant Bovine C-X-C chemokine receptor type 2 (CXCR2)	in vitro E.coli expression system

CXCR2 Proteins for Gorilla gorilla gorilla (Lowland gorilla)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP636722GGZ1 CSB-EP636722GGZ1 CSB-BP636722GGZ1 CSB-MP636722GGZ1 CSB-EP636722GGZ1-B	Recombinant Gorilla gorilla gorilla C-X-C chemokine receptor type 2 (CXCR2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF636722GGZ	Recombinant Gorilla gorilla gorilla C-X-C chemokine receptor type 2 (CXCR2)	in vitro E.coli expression system