CX3CL1

CX3CL1蛋白全稱為C-X3-C基序趨化因子配體1，別名CXC3。這種獨(dú)特的趨化因子以跨膜形式存在于細(xì)胞表面，同時(shí)可被酶切釋放為可溶形式，兼具細(xì)胞黏附和趨化雙重功能。CX3CL1通過結(jié)合CX3CR1受體，在單核細(xì)胞、T細(xì)胞和神經(jīng)小膠質(zhì)細(xì)胞的遷移中起關(guān)鍵作用，尤其在神經(jīng)免疫交互中表現(xiàn)突出。
CX3CL1與阿爾茨海默病、帕金森病等神經(jīng)退行性疾病密切相關(guān)，腦內(nèi)小膠質(zhì)細(xì)胞通過CX3CL1-CX3CR1軸調(diào)控神經(jīng)炎癥進(jìn)程。在心血管領(lǐng)域，CX3CL1參與動(dòng)脈粥樣硬化斑塊形成，促進(jìn)單核細(xì)胞向血管壁浸潤。針對(duì)該通路的藥物開發(fā)已進(jìn)入臨床試驗(yàn)階段，例如E6011單抗通過阻斷CX3CL1-CX3CR1相互作用，在類風(fēng)濕性關(guān)節(jié)炎和狼瘡性腎炎治療中顯示出潛力。阿爾茨海默病動(dòng)物模型中，抑制該通路可減少β淀粉樣蛋白沉積，為神經(jīng)退行性疾病治療提供了新方向。

熱銷產(chǎn)品

Recombinant Human Fractalkine (CX3CL1), partial, Biotinylated (CSB-MP006235HU-B)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CX3CL1 Antibody (CSB-PA06087A0Rb)

驗(yàn)證數(shù)據(jù)

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA06087A0Rb at dilution of 1:100

Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA06087A0Rb at dilution of 1:100

Immunofluorescent analysis of Hela cells cells using CSB-PA06087A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

CX3CL1 Antibody

CX3CL1 Protein

CX3CL1 ELISA Kit

CX3CL1 Antibodies

CX3CL1 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA06087A0Rb	CX3CL1 Antibody	Human	ELISA, IHC, IF
CSB-PA006235GA01HU	CX3CL1 Antibody	Human	ELISA,WB
CSB-PA005564	CX3CL1 Antibody	Human	WB, ELISA
CSB-PA092112	CX3CL1 Antibody	Human,Mouse,Rat	ELISA,IHC

CX3CL1 Proteins

CX3CL1 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP006235HU CSB-EP006235HU CSB-BP006235HU CSB-MP006235HU CSB-EP006235HU-B	Recombinant Human Fractalkine (CX3CL1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP006235HU(F)	Recombinant Human Fractalkine (CX3CL1), partial	E.coli
CSB-AP000801HU	Recombinant Human Fractalkine protein (CX3CL1), partial (Active)	E.Coli
CSB-MP006235HU-B	Recombinant Human Fractalkine (CX3CL1), partial, Biotinylated	Mammalian cell

CX3CL1 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP006235MO1 CSB-EP006235MO1 CSB-BP006235MO1 CSB-MP006235MO1 CSB-EP006235MO1-B	Recombinant Mouse Fractalkine (Cx3cl1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-AP001211MO	Recombinant Mouse Fractalkine protein (Cx3cl1), partial (Active)	E.Coli
CSB-CF006235MO	Recombinant Mouse Fractalkine (Cx3cl1)	in vitro E.coli expression system

CX3CL1 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP006235RA1 CSB-EP006235RA1 CSB-BP006235RA1 CSB-MP006235RA1 CSB-EP006235RA1-B	Recombinant Rat Fractalkine (Cx3cl1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-AP001511RA	Recombinant Rat Fractalkine protein (Cx3cl1), partial (Active)	E.Coli
CSB-CF006235RA	Recombinant Rat Fractalkine (Cx3cl1)	in vitro E.coli expression system