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CSF1

Csf1,全稱為Macrophage colony-stimulating factor 1,常見別名包括M-CSF、CSF-1等。該蛋白在免疫系統(tǒng)中扮演著重要角色,能夠促進巨噬細胞的增殖、分化和存活,并調(diào)控其功能。Csf1蛋白通過與細胞表面的CSF1R(又稱CD115)結(jié)合發(fā)揮生物學效應,參與多種生理過程,如組織修復、骨代謝平衡維持等。近年來,研究發(fā)現(xiàn)Csf1蛋白與多種疾病的發(fā)生發(fā)展密切相關(guān),包括腫瘤、免疫疾病和代謝性疾病等。在腫瘤微環(huán)境中,Csf1蛋白能夠招募和極化巨噬細胞為M2型(促腫瘤表型),促進腫瘤血管生成、免疫抑制和轉(zhuǎn)移。因此,Csf1蛋白及其受體CSF1R已成為腫瘤治療的重要靶點。目前,針對Csf1/CSF1R通路的靶向藥物研發(fā)取得了一定的進展,部分藥物已進入臨床研究階段,為腫瘤治療提供了新的策略。

熱銷產(chǎn)品

Recombinant Human Macrophage colony-stimulating factor 1 (CSF1), partial (Active) (CSB-MP006043HU1)

驗證數(shù)據(jù)

CSB-MP006043HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP006043HU1

Activity
The ED50 as determined by the dose-dependent stimulation of the proliferation of THP-1 cells is 2.880-4.115 ng/mL.

CSB-MP006043HU1

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CSF1 protein at 2 μg/ml can bind Anti-CSF1 recombinant antibody (CSB-RA006043MA1HU). The EC50 is 4.291-4.988 ng/mL.

CSB-MP006043HU1

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CSF1 protein at 2 μg/ml can bind Human CSF1R protein (CSB-MP006044HU). The EC50 is 37.37-43.34 ng/mL.

CSB-MP006043HU1

CSF1 Recombinant Monoclonal Antibody (CSB-RA006043MA1HU) captured on Protein A Chip can bind Recombinant Human CSF1 protein with an affinity constant of 0.13 nM as detected by MetaSPR Assay (WeSPRTM 200).

Recombinant Human Macrophage colony-stimulating factor 1 (CSF1), partial (Active) (CSB-YP006043HU1)

驗證數(shù)據(jù)

CSB-YP006043HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-YP006043HU1

Activity
The ED50 as determined by the dose-dependent stimulation of the proliferation of THP-1 cells is 0.5913-1.205 ng/mL.

CSB-YP006043HU1

The purity of CSF1 was greater than 90% as determined by SEC-HPLC

Recombinant Human Macrophage colony-stimulating factor 1 (CSF1), partial (Active) (CSB-MP006043HU1)

驗證數(shù)據(jù)

CSB-MP006043HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP006043HU1

Activity
The ED50 as determined by the dose-dependent stimulation of the proliferation of THP-1 cells is 2.880-4.115 ng/mL.

CSB-MP006043HU1

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CSF1 protein at 2 μg/ml can bind Anti-CSF1 recombinant antibody (CSB-RA006043MA1HU). The EC50 is 4.291-4.988 ng/mL.

CSB-MP006043HU1

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CSF1 protein at 2 μg/ml can bind Human CSF1R protein (CSB-MP006044HU). The EC50 is 37.37-43.34 ng/mL.

CSB-MP006043HU1

CSF1 Recombinant Monoclonal Antibody (CSB-RA006043MA1HU) captured on Protein A Chip can bind Recombinant Human CSF1 protein with an affinity constant of 0.13 nM as detected by MetaSPR Assay (WeSPRTM 200).

Recombinant Mouse Macrophage colony-stimulating factor 1 (Csf1), partial (Active) (CSB-MP006043MO)

驗證數(shù)據(jù)

CSB-MP006043MO

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP006043MO

Activity
Measured by its binding ability in a functional ELISA.Immobilized Mouse Csf1 at 2 μg/ml can bind Mouse Csf1r(CSB-MP006044MO). The EC50 is 3.226-4.264 ng/mL.

CSB-MP006043MO

The purity of Csf1 was greater than 90% as determined by SEC-HPLC

CSF1 Antibody (CSB-PA06859A0Rb)

驗證數(shù)據(jù)

CSB-PA06859A0Rb

Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA06859A0Rb at dilution of 1:100

CSB-PA06859A0Rb

Immunofluorescent analysis of A549 cells using CSB-PA06859A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Human Macrophage Colony-Stimulating Factor,M-CSF ELISA kit (CSB-E04658h)

驗證數(shù)據(jù)

CSB-E04658h 標準曲線

貨號:CSB-E04658h

規(guī)格:96T/48T

靈敏度:0.039 ng/ml

檢測范圍:0.156 ng/ml - 10 ng/ml

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

CSF1 Antibodies

CSF1 for Mus musculus (Mouse)

CSF1 for Homo sapiens (Human)

CSF1 Proteins

CSF1 Proteins for Mus musculus (Mouse)

CSF1 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

CSF1 Proteins for Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)

CSF1 Proteins for Rattus norvegicus (Rat)

CSF1 Proteins for Homo sapiens (Human)

CSF1 ELISA Kit

CSF1 ELISA Kit for Homo sapiens (Human)

CSF1 ELISA Kit for Mus musculus (Mouse)

CSF1 ELISA Kit for Rattus norvegicus (Rat)



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