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CRLF2

CDLF2,即細(xì)胞因子受體樣因子2,別名CRLF2。它是由人類(lèi)CRLF2基因編碼的I型細(xì)胞因子受體家族成員。CRLF2蛋白是胸腺基質(zhì)淋巴生成素(TSLP)的受體,與白細(xì)胞介素7受體(IL7R)一起,能夠激活STAT3、STAT5和JAK2途徑,這些途徑控制著細(xì)胞增殖和造血系統(tǒng)發(fā)育等過(guò)程。CRLF2的作用機(jī)制涉及與TSLP和IL7R形成功能性復(fù)合體,通過(guò)激活JAK-STAT信號(hào)通路來(lái)刺激細(xì)胞增殖。CRLF2在正常B淋巴細(xì)胞的發(fā)育中起重要作用,但在急性淋巴細(xì)胞白血病(ALL)中,CRLF2的過(guò)表達(dá)或重排與疾病的發(fā)生發(fā)展有關(guān),尤其是在Ph樣ALL(費(fèi)城染色體樣急性淋巴細(xì)胞白血病)中,CRLF2的重排導(dǎo)致細(xì)胞表面CRLF2高表達(dá),刺激前B淋巴細(xì)胞增殖,與不良預(yù)后相關(guān)。

熱銷(xiāo)產(chǎn)品

Recombinant Macaca fascicularis cytokine receptor-like factor 2 (CRLF2), partial (Active) (CSB-MP5357MOV)

驗(yàn)證數(shù)據(jù)

CSB-MP5357MOV

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP5357MOV

Activity
Measured by its binding ability in a functional ELISA.Immobilized Macaca fascicularis TSLP(CSB-MP5042MOVd7-B) at 2 μg/ml on streptavidin coated plates can bind Macaca fascicularis CRLF2 protein. The EC50 is 2.698-3.710 ng/mL.

Recombinant Macaca fascicularis cytokine receptor-like factor 2 (CRLF2), partial (Active) (CSB-MP5357MOVd7)

驗(yàn)證數(shù)據(jù)

CSB-MP5357MOVd7

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP5357MOVd7

Activity
Measured by its binding ability in a functional ELISA.Immobilized Macaca fascicularis CRLF2 at 2 μg/ml can bind Anti-CRLF2 recombinant antibody(CSB-RA005983MA1HU). The EC50 is 2.079-2.450 ng/mL.

Recombinant Human Cytokine receptor-like factor 2 (CRLF2), partial, Biotinylated (Active) (CSB-MP005983HU-B)

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CSB-MP005983HU-B

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP005983HU-B

Activity
Measured by its binding ability in a functional ELISA.Immobilized Human CRLF2 at 2 μg/ml on streptavidin coated plates can bind Anti-CRLF2 recombinant antibody(CSB-RA005983MA1HU). The EC50 is 3.631-7.668 ng/mL.

Recombinant Human Cytokine receptor-like factor 2 (CRLF2), partial (Active) (CSB-MP005983HUd9)

驗(yàn)證數(shù)據(jù)

CSB-MP005983HUd9

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP005983HUd9

Activity
Measured by its binding ability in a functional ELISA.Immobilized Human TSLP(CSB-MP025141HUh7) at 2 μg/ml can bind Human CRLF2 protein.The EC50 is 41.01-45.10 ng/mL.

CSB-MP005983HUd9

The purity of CRLF2 was greater than 95% as determined by SEC-HPLC

Recombinant Human Cytokine receptor-like factor 2 (CRLF2), partial (Active) (CSB-MP005983HU)

驗(yàn)證數(shù)據(jù)

CSB-MP005983HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP005983HU

Activity
Measured by its binding ability in a functional ELISA.Immobilized Human CRLF2 at 2 μg/ml can bind Anti-CRLF2 recombinant antibody(CSB-RA005983MA1HU). The EC50 is 1.630-1.842 ng/mL.

CRLF2 Antibody (CSB-PA005983ESR1HU)

驗(yàn)證數(shù)據(jù)

CSB-PA005983ESR1HU

Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA005983ESR1HU at dilution of 1:100

CSB-PA005983ESR1HU

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA005983ESR1HU at dilution of 1:100

CRLF2 Antibodies

CRLF2 for Homo sapiens (Human)

CRLF2 Proteins

CRLF2 Proteins for Mus musculus (Mouse)

CRLF2 Proteins for Rattus norvegicus (Rat)

CRLF2 Proteins for Homo sapiens (Human)



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