COL18A1，作為膠原蛋白家族的重要成員，具有獨(dú)特的分子結(jié)構(gòu)，通過(guò)其特定的氨基酸序列在細(xì)胞外基質(zhì)中發(fā)揮關(guān)鍵作用。在功能上，COL18A1不僅參與視網(wǎng)膜的形成和維持，確保視網(wǎng)膜正常功能，還調(diào)節(jié)內(nèi)皮細(xì)胞的遷移、增殖和粘附等過(guò)程，對(duì)血管生成、傷口愈合以及胎盤(pán)循環(huán)建立至關(guān)重要。同時(shí)，COL18A1能夠特異性地抑制內(nèi)皮細(xì)胞增殖和血管生成，通過(guò)抑制內(nèi)皮細(xì)胞遷移和粘附，下調(diào)血管生成相關(guān)基因表達(dá)來(lái)實(shí)現(xiàn)。在信號(hào)通路上，COL18A1通過(guò)與內(nèi)皮細(xì)胞表面受體結(jié)合，觸發(fā)一系列細(xì)胞內(nèi)信號(hào)轉(zhuǎn)導(dǎo)，涉及轉(zhuǎn)谷氨酰胺酶2、肝素、整合素α5 beta 1和αV beta 3等分子的相互作用，導(dǎo)致細(xì)胞骨架重排、基因表達(dá)改變以及細(xì)胞行為調(diào)整。此外，COL18A1的突變與某些疾病如諾布洛赫綜合征相關(guān)，突顯其在維持正常生理功能和預(yù)防疾病中的重要作用。盡管我們對(duì)COL18A1已有一定了解，但仍需進(jìn)一步探索其未知領(lǐng)域，以揭示其在生理和病理過(guò)程中的更多作用，并為新治療策略的開(kāi)發(fā)提供線索。

熱銷(xiāo)產(chǎn)品

Recombinant Human Collagen alpha-1 (XVIII) chain (COL18A1), partial

驗(yàn)證數(shù)據(jù)

SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

LCMS

Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP005725HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) COL18A1.

LCMS

Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP005725HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) COL18A1.