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CLDN6

CLDN6,全稱Claudin-6,是緊密連接蛋白家族的一員,主要在上皮細胞和內皮細胞中表達。它是一種腫瘤特異性蛋白,在多種實體腫瘤中表達上調,包括卵巢癌、宮頸癌、子宮內膜癌、睪丸癌等,但在健康成人組織中幾乎不表達。CLDN6在細胞連接和上皮組織通透性中發揮重要作用,其異常表達與許多腫瘤的發生和發展密切相關,因此被視為實體瘤領域的重要治療靶點。目前,全球已有超過30款針對CLDN6的在研藥物,包括單抗、雙抗、ADC、CAR-T等多種類型,其中部分藥物已進入臨床階段,并顯示出對多種實體瘤的治療潛力和良好的安全性。例如,BioNTech開發的BNT211 CAR-T療法和BNT142體內生成式雙抗療法,以及TORL BioTherapeutics開發的TORL-1-23 ADC藥物等,均取得了積極的臨床結果,為實體瘤患者帶來了新的治療選擇。

熱銷產品

Recombinant Human Claudin-6(CLDN6)-Detergent (Active) (CSB-MP005508HU(A5)-D)

驗證數據

CSB-MP005508HU(A5)-D

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP005508HU(A5)-D

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CLDN6 at 2 μg/ml can bind Anti-CLDN6/9 recombinant antibody (CSB-RA005508MA1HU). The EC50 is 1.243-2.426 ng/mL.

CSB-MP005508HU(A5)-D

Activity
Human CLDN6 Monoclonal Antibody (CSB-RA005508MA1HU) captured on Protein A Chip can bind Human CLDN6 Full Length Protein with an affinity constant of 5.43 nM as detected by MetaSPR Assay(in presence of DDM/CHS) (WeSPRTM 200).

Recombinant Human Claudin-6 (CLDN6), partial-VLPs (CSB-MP005508HU2)

驗證數據

CSB-MP005508HU2

CSB-MP005508HU2 is detected by Mouse anti-6*His monoclonal antibody

CSB-MP005508HU2

The purity of VLPs was greater than 95% as determined by SEC-HPLC

CLDN6/9 Monoclonal Antibody (CSB-RA005508MA1HU)

驗證數據

CSB-RA005508MA1HU

The Binding Activity of Huamn CLDN6 with Anti-CLDN6/9 recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN6 (CSB-MP005508HU(A4)) at 10 μg/mL can bind Anti-CLDN6/9 recombinant antibody, the EC50 is 1.501-2.035 ng/mL.

CSB-RA005508MA1HU

The Binding Activity of Human CLDN9 with Anti-CLDN6/9 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN9 (CSB-MP005511HU) at 10 μg/mL can bind Anti-CLDN6/9 recombinant antibody, the EC50 is 24.93-35.47 ng/mL.

CSB-RA005508MA1HU

Untransfected HEK293T cells surface (green line) and transfected Human CLDN6 HEK293T stable cells surface (red line) were stained with anti-CLDN6/9 recombinant antibody (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CSB-RA005508MA1HU

Untransfected MC38 cells (green line) and transfected Human CLDN9 MC38 stable cells (red line) were stained with anti-CLDN6/9 antibody (2μg/1*106cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CSB-RA005508MA1HU

Untransfected CHO-K1*106cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CSB-RA005508MA1HU

Untransfected MC38 cells (green line) and transfected Human CLDN6 MC38 stable cells (red line) were stained with anti-CLDN6/9 antibody (2μg/1*106cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CSB-RA005508MA1HU

The Binding Activity of Macaca fascicularis CLDN6 with Anti-CLDN6/9 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis CLDN6(CSB-MP6148GKN) at 5 μg/mL can bind Anti-CLDN6/9 recombinant antibody. The EC50 is 4.186-6.635 ng/mL.
The VLPs (CSB-MP3838) is negative control.

CSB-RA005508MA1HU

The Binding Activity of Human CLDN6 with Anti-CLDN6/9 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN6 (CSB-MP005508HU(A5)-D) at 2 μg/mL can bind Anti-CLDN6/9 recombinant antibody. The EC50 is 1.243-2.426 ng/mL.

CSB-RA005508MA1HU

The Binding Activity of Human CLDN9 with Anti-CLDN6/9 Recombinant Antibody
Activity:Measured by its binding ability in a functional ELISA. Immobilized Human CLDN9 (CSB-MP005511HU-D) at 2 μg/ml on an Nickel Coated plate can bind Anti-CLDN6/9 recombinant antibody. The EC50 is 2.812-3.524 ng/mL.

CSB-RA005508MA1HU

The Binding Activity of Mouse cldn6 with Anti-CLDN6/9 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse cldn6(CSB-MP3347MO) at 5 μg/mL can bind Anti-CLDN6/9 recombinant antibody. The EC50 is 4.027-6.270 ng/mL.

CLDN6 Antibody (CSB-PA005508LA01HU)

驗證數據

CSB-PA005508LA01HU

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA005508LA01HU at dilution of 1:100

CSB-PA005508LA01HU

Immunofluorescence staining of HepG2 cells with CSB-PA005508LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CLDN6 Antibodies

CLDN6 for Homo sapiens (Human)

CLDN6 Proteins

CLDN6 Proteins for Homo sapiens (Human)

CLDN6 Proteins for Homo sapiens(Human)



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