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CLDN1

CLDN1,全稱Claudin-1,是一種重要的緊密連接蛋白,在維持細胞間屏障功能方面發揮著關鍵作用。它主要參與形成細胞間的緊密連接結構,調節細胞旁通透性,以及維持上皮細胞和內皮細胞層的細胞間黏附。CLDN1在多種組織中表達,包括皮膚、肺、胃、腎臟等。其異常表達與多種疾病的發生發展相關,如魚鱗病、白細胞空泡、脫發、硬化性膽管炎綜合征、頭頸鱗狀細胞癌、肝細胞癌、結直腸癌、胃癌、卵巢癌、胰腺癌和甲狀腺癌等。目前,針對CLDN1的藥物研發取得了一定的進展,例如Alentis Therapeutics開發的靶向CLDN1的單抗ALE.C04,以及雙特異性抗體ASP1002等,均處于臨床試驗階段,顯示出在腫瘤治療和器官纖維化疾病治療方面的潛力。

熱銷產品

Recombinant Human Claudin-1 (CLDN1)-VLPs (Active) (CSB-MP005490HU)

驗證數據

CSB-MP005490HU

CSB-MP005490HU is detected by Mouse anti-6*His monoclonal antibody.

CSB-MP005490HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CLDN1 at 10 μg/ml can bind Anti-CLDN1 recombinant antibody (CSB-RA005490MA1HU). The EC50 is 35.03-50.71 ng/mL. The VLPs (CSB-MP3838) is negative control.

CSB-MP005490HU

The purity of VLPs was greater than 95% as determined by SEC-HPLC

Recombinant Human Claudin-1 (CLDN1)-Detergent (Active) (CSB-MP005490HU1-D)

驗證數據

CSB-MP005490HU1-D

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP005490HU1-D

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CLDN1 at 2 μg/ml on an Nickel Coated plate can bind Anti-CLDN1 recombinant antibody (CSB-RA005490MA1HU). The EC50 is 62.47-72.10 ng/mL.

Recombinant Human Claudin-1 (CLDN1) (CSB-CF005490HU)

驗證數據

CSB-CF005490HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CLDN1 Antibody (CSB-PA005490LA01HU)

驗證數據

CSB-PA005490LA01HU

Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA005490LA01HU at dilution of 1:100

CSB-PA005490LA01HU

Immunofluorescent analysis of HepG2 cells using CSB-PA005490LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Human Claudin-1(CLDN1) ELISA kit (CSB-EL005490HU)

驗證數據

CSB-EL005490HU 標準曲線

貨號:CSB-EL005490HU

規格:96T/48T

靈敏度:3.9 pg/mL

檢測范圍:15.6 pg/mL-1000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

CLDN1 Antibodies

CLDN1 for Homo sapiens (Human)

CLDN1 Proteins

CLDN1 Proteins for Homo sapiens (Human)

CLDN1 ELISA Kit

CLDN1 ELISA Kit for Homo sapiens (Human)



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