CHRNB2
神經元煙堿型乙酰膽堿受體β2亞基(CHRNB2)是神經系統重要的膜蛋白組分,常被稱為nAChR β2亞基。這類蛋白質廣泛分布于大腦皮層、丘腦等區域,通過與乙酰膽堿結合形成離子通道,調控神經遞質的釋放與神經元興奮性。CHRNB2參與維持覺醒狀態、認知功能及痛覺感知,其功能異常可能引發癲癇、阿爾茨海默病及尼古丁成癮。某些家族性癲癇病例中已發現該亞基基因突變會導致神經元過度興奮。
近年來針對β2亞基的藥物開發聚焦于神經系統疾病領域。例如伐尼克蘭作為α4β2受體部分激動劑,已用于戒煙治療并顯示出調節多巴胺釋放的潛力。在抗癲癇藥物篩選中,特定小分子化合物通過增強β2亞基介導的電流展現出調控神經元網絡同步性的作用。此外,該亞基與β淀粉樣蛋白的相互作用機制正成為阿爾茨海默病研究的新方向,相關抗體藥物已進入臨床前評估階段。
熱銷產品
Recombinant Human Neuronal acetylcholine receptor subunit beta-2 (CHRNB2), partial (CSB-EP005396HU1)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CHRNB2 Antibody (CSB-PA005396LA01HU)
驗證數據
Western Blot
Positive WB detected in: Jurkat whole cell lysate
All lanes: CHRNB2 antibody at 6.05μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 58 kDa
Observed band size: 58 kDa
Immunofluorescence staining of SH-SY5Y cells with CSB-PA005396LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
IHC image of CSB-PA005396LA01HU diluted at 1:400 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
CHRNB2 Antibodies
CHRNB2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA005396LA01HU | CHRNB2 Antibody | Human, Rat | ELISA, WB, IHC, IF |
CHRNB2 Proteins
CHRNB2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP005396HU1 CSB-BP005396HU1 CSB-MP005396HU1 CSB-EP005396HU1-B |
Recombinant Human Neuronal acetylcholine receptor subunit beta-2 (CHRNB2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF005396HU | Recombinant Human Neuronal acetylcholine receptor subunit beta-2 (CHRNB2) | in vitro E.coli expression system |
| CSB-EP005396HU1 | Recombinant Human Neuronal acetylcholine receptor subunit beta-2 (CHRNB2), partial | E.coli |






