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CHEK2

Serine/threonine-protein kinase Chk2 is a protein in humans that is encoded by CHEK2 gene. Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression.

CHEK2 Antibodies

CHEK2 for Homo sapiens (Human)

CHEK2 Proteins

CHEK2 Proteins for Homo sapiens (Human)



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